A North American perspective on the ESNM consensus statement on gastroparesis

Published on May 17, 2021in Neurogastroenterology and Motility2.946
· DOI :10.1111/NMO.14174
Michael Camilleri146
Estimated H-index: 146
(Mayo Clinic),
Saam Dilmaghani (Mayo Clinic)+ 1 AuthorsTing Zheng (Mayo Clinic)
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#1Yizhou Ye (Takeda Pharmaceutical Company)H-Index: 3
#2Baoguo Jiang (Takeda Pharmaceutical Company)H-Index: 2
Last. Alexander C. FordH-Index: 86
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Objective To generate real-world evidence for the epidemiology of gastroparesis in the UK, we evaluated the prevalence, incidence, patient characteristics and outcomes of gastroparesis in the Clinical Practice Research Datalink (CPRD) database. Design This was a retrospective, cross-sectional study. Prevalence and incidence of gastroparesis were evaluated in the CPRD database, with linkage to Hospital Episodes Statistics Admitted Patient Care and Office for National Statistics mortality data. Pr...
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#1P. J. Pasricha (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 11
#1Pankaj J. Pasricha (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 80
Last. Katherine Yates (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 5
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Background The aim of this study was to clarify the pathophysiology of functional dyspepsia (FD), a highly prevalent gastrointestinal syndrome, and its relationship with the better-understood syndrome of gastroparesis. Methods Adult patients with chronic upper gastrointestinal symptoms were followed up prospectively for 48 weeks in multi-center registry studies. Patients were classified as having gastroparesis if gastric emptying was delayed; if not, they were labeled as having FD if they met Ro...
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#1Susrutha Puthanmadhom Narayanan (Mayo Clinic)H-Index: 3
#2Daniel R. O'Brien (Mayo Clinic)H-Index: 17
Last. Adil E. Bharucha (Mayo Clinic)H-Index: 69
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Hindered by a limited understanding of the mechanisms responsible for diabetic gastroenteropathy (DGE), management is symptomatic. We investigated the duodenal mucosal expression of protein-coding genes and microRNAs (miRNA) in DGE and related them to clinical features. The diabetic phenotype, gastric emptying, mRNA, and miRNA expression and ultrastructure of duodenal mucosal biopsies were compared in 39 DGE patients and 21 controls. Among 3175 differentially expressed genes (FDR < 0.05), severa...
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#1Jesse L. CarlinH-Index: 2
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Abstract Background & Aims Treatments are needed for gastroparesis; antagonists of tachykinin receptor 1 (TACR1, also called NK1R) can reduce symptoms of nausea and vomiting. We investigated the safety and efficacy of tradipitant, an antagonist of NK1R, in patients with idiopathic or diabetic gastroparesis. Methods We performed a double-blind trial of 152 adults with gastroparesis at 47 sites in the United States from November 2016 through December 2018. Participants were randomly assigned to gr...
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#1Berkeley N Limketkai (UCLA: University of California, Los Angeles)H-Index: 6
#2Wendi LeBrett (UCLA: University of California, Los Angeles)H-Index: 1
Last. Neha D Shah (UCSF: University of California, San Francisco)H-Index: 1
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Patients with gastroparesis often have signs and symptoms including nausea, vomiting, epigastric discomfort, and early satiety, thus leading to inadequate food intake and a high risk of malnutrition. There is a considerable scarcity of data about nutritional strategies for gastroparesis, and current practices rely on extrapolated evidence. Some approaches include the modification of food composition, food consistency, and food volume in the context of delayed gastric emptying. If the patient is ...
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ABSTRACT Background and Aims Endoluminal functional luminal imaging probe (EndoFLIP) is an imaging tool that measures physiological characteristics of gastrointestinal sphincters. In this study we used EndoFLIP to evaluate the association between the pyloric physiological measurements with clinical outcomes of gastric peroral endoscopic myotomy (G-POEM) in patients with refractory gastroparesis. Methods Thirty-seven patients who underwent G-POEM for management of refractory gastroparesis and had...
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#1Andres Gottfried-Blackmore (Stanford University)H-Index: 1
#1Andres Gottfried-Blackmore (Stanford University)H-Index: 13
Last. Linda Nguyen (Stanford University)H-Index: 19
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BACKGROUND: Gastroparesis, a chronic motility disorder characterized by delayed gastric emptying, abdominal pain, nausea, and vomiting, remains largely unexplained. Medical therapy is limited, reflecting the complex physiology of gastric sensorimotor function. Vagus nerve stimulation is an attractive therapeutic modality for gastroparesis, but prior methods required invasive surgery. In this open-label pilot study, we aimed to assess the benefit of non-invasive vagal nerve stimulation in patient...
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#1Linda Nguyen (Stanford University)H-Index: 19
#2Laura A. Wilson (Johns Hopkins University)H-Index: 30
Last. Thomas L. Abell (University of Louisville)H-Index: 19
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BACKGROUND: Autonomic dysfunction can be present in patients with idiopathic and diabetic gastroparesis. The role of autonomic dysfunction relating to gastric emptying and upper gastrointestinal symptoms in patients with gastroparesis and chronic unexplained nausea and vomiting (CUNV) remains unclear. The aim of our study is to evaluate autonomic function in patients with gastroparesis and CUNV with respect to etiology, gastric emptying and symptom severity. METHODS: We studied 242 patients with...
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#1Philippe Ducrotté (French Institute of Health and Medical Research)H-Index: 57
#1Philippe Ducrotté (French Institute of Health and Medical Research)H-Index: 2
Last. Pierre Fontaine (University of Toulouse)H-Index: 1
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Abstract Background & Aims There have been conflicting results from trials of gastric electrical stimulation (GES) for treatment of refractory vomiting, associated or not with gastroparesis. We performed a large, multicenter, randomized, double-blind trial with cross-over to study the efficacy of GES in patients with refractory vomiting, with or without gastroparesis. Methods For 4 months, we assessed symptoms in 172 patients (66% women; mean age 45±12 years; 133 with gastroparesis) with chronic...
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#1Arielle M Lee (UCSD: University of California, San Diego)H-Index: 3
#2Karl-Hermann Fuchs (UCSD: University of California, San Diego)H-Index: 21
Last. Santiago Horgan (UCSD: University of California, San Diego)H-Index: 30
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Introduction Delayed gastric emptying (DGE) can be caused by gastric motility disorders such as gastroparesis with idiopathic background, diabetic neuropathy, or postsurgical nerve damage. Currently, a variety of endoscopic and surgical treatment options are available. We noted clinical improvement of gastric emptying with reduction of the gastric fundus following both fundoplication and fundectomy. As a consequence, we explored the effect of sleeve gastrectomy on gastric emptying. The focus of ...
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