A review on the applications of electrospun chitosan nanofibers for the cancer treatment.

Published on Jul 31, 2021in International Journal of Biological Macromolecules5.162
· DOI :10.1016/J.IJBIOMAC.2021.05.009
Abstract In recent years, the incidence of cancer is increasing every day due to poor quality of life (industrialization of life). Therefore, the treatment of cancer has received much attention from therapists. So far, many anticancer drugs have been used to treat cancer patents. However, the direct use of the anticancer drugs has the adverse side effects for patents and several limitations to treat process. Natural chitosan nanofibers prepared by electrospinning method have unique properties such as high surface area, high porosity, suitable mechanical properties, nontoxicity, biocompatibility, biodegradability, biorenewable, low immunogenicity, better clinical functionality, analogue to extracellular model, and easy production in large scale. Therefore, this bio-polymer is a very suitable case to deliver of the anti-cancer drugs to treat cancer patents. In this review summarizes the electrospinning synthesis of chitosan and its therapeutic application for the various cancer treatment.
#1Sareh Sepahi (University of Qom)H-Index: 1
#2Mohammadreza Kalaee (IAU: Islamic Azad University)H-Index: 14
Last. Seyede Mahtab Hosseini (AUT: Amirkabir University of Technology)H-Index: 1
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The use of electrospun membrane is of great importance to control the drug release rate and improve the remedial performance. In this work, etched halloysite nanotubes (eHNTs) loaded with Amoxicillin (AMX) were imbedded in poly(lactic acid) (PLA) solution and were electrospun to make nanocomposite fibrous web. The morphology, uniformity, and size of electrospun (PLA/eHNTs/AMX) nanocomposite fibers were evaluated by scanning electron microscopy (SEM). Fourier-transform infrared spectroscopy (FTIR...
#1Arezo Nouri (University of Sistan and Baluchestan)H-Index: 4
#2Babak Faraji Dizaji (EMU: Eastern Mediterranean University)H-Index: 5
Last. Fariborz Sharifian Jazi (AUT: Amirkabir University of Technology)H-Index: 4
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The folic acid (FA) and doxorubicin (DOX) have been doped into the g-C3 N4 /MoS2 incorporated-chitosan/ethyl cellulose (EC) core-shell nanofibers for targeted delivery of FA and DOX against HeLa and MCF-7 cell lines. The g-C3 N4 /MoS2 nanosheets and core-shell nanofibers were characterized using Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and UV-Vis tests. The drug loading factor, the degradation rate, and the DOX an...
3 CitationsSource
#1Saeideh Khalaji (TMU: Tarbiat Modares University)H-Index: 1
#2Nadereh Golshan Ebrahimi (TMU: Tarbiat Modares University)H-Index: 12
Last. Hossein HosseinkhaniH-Index: 46
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AbstractA biocompatible synthetic polymer, poly(vinyl alcohol) (PVA), and a water-soluble derivative of chitosan, (N-[(2-hydroxy-3-trimethyl-ammonium)-propyl] chitosan chloride) (HTCC), were blende...
4 CitationsSource
#1Zahra Amini (Tehran University of Medical Sciences)H-Index: 2
#2Sam Shekofte Rudsary (IAU: Islamic Azad University)H-Index: 1
Last. Fariborz Sharifianjazi (AUT: Amirkabir University of Technology)H-Index: 15
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Abstract The bioactive glasses (BGs)/Cisplatin and magnetic bioactive glasses (MBGs)/Cisplatin were doped into the chitosan (CS)-grafted- poly (ɛ-caprolactone) (PCL) nanofibers for controlled release of Cisplatin under various pH values and temperatures. The simultaneous effect of chemotherapy and hyperthermia was investigated against MG-63 osteosarcoma cells by treating of cells with Cs-g-PCL/MBGs/Cisplatin under an alternating magnetic field. The synthesized nanofibers were characterized using...
#1Mahdi Abasalta (IAU: Islamic Azad University)H-Index: 1
#2Azadeh Asefnejad (IAU: Islamic Azad University)H-Index: 12
Last. Ahmad Ramazani Saadatabadi (Sharif University of Technology)H-Index: 6
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Abstract The coaxial electrospinning for producing core-shell nanofibers due to control the release profile of drug by the shell layer has been developed. N-carboxymethyl chitosan (CMC)-polyvinyl alcohol (core)/poly(e-caprolactone) (PCL) (shell) nanofibers were produced via coaxial electrospinning. Doxorubicin (DOX) and nickel ferrite nanoparticles were incorporated into the nanofibers for controlled release of DOX against MCF-7 breast cancer. The minimum CMC/PCL fiber diameter was found to be 3...
1 CitationsSource
#1Wei Pan (Qingdao Agricultural University)H-Index: 12
#2Jinping Wang (Qingdao Agricultural University)H-Index: 12
Last. Gui-Feng Yu (Qingdao University)H-Index: 10
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Abstract A novel facile fabrication method was adopted for the first time to fabricate continuous, uniform, and stable metal-organic framework-5 (MOF-5), supported on flexible and freestanding electrospun chitosan/(polyethylene oxide) (PEO) membrane fibers with comprehensive PM2.5 removal properties at room temperature. Carboxyl groups were introduced to connect amino groups on the chitosan nanofibers at an early stage; Zn2+ then had the opportunity for uniform chemical bonding to the surface of...
#1Jamie GrantH-Index: 1
#2Suresh C. PillaiH-Index: 48
Last. Ailish BreenH-Index: 11
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Electrospun nanofibrous mats consisting of chitosan (CS) and polyvinylpyrrolidone (PVP) were constructed. Tuning of solution and process parameters was performed and resulted in an electrospun system containing a 6:4 ratio of PVP:CS. This is a significant increase in the proportion of spun CS on the previously reported highest ratio PVP:CS blend. SEM analysis showed that the nanofibrous mats with 4 wt% CS/6 wt% PVP (sample E) comprised homogenous, uniform fibres with an average diameter of 0.569...
1 CitationsSource
#1Quanfu Xu (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Yu-Li Yang (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Yi-Gang Li (SJTU: Shanghai Jiao Tong University)H-Index: 19
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BACKGROUND End-stage heart failure is a major risk of mortality. The conductive super-aligned carbon nanotubes sheets (SA-CNTs) has been applied to restore the structure and function of injured myocardium through tissue engineering, and developed as efficient cardiac pacing electrodes. However, the interfacial interaction between SA-CNTs and the surface cells is unclear, and it remains challenge to restore the diminished contraction for a seriously damaged heart. RESULTS A concept of a multifunc...
1 CitationsSource
#1Maryam Hajiabbas (Sharif University of Technology)H-Index: 5
#2Iran Alemzadeh (Sharif University of Technology)H-Index: 22
Last. Manouchehr Vossoughi (Sharif University of Technology)H-Index: 36
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#1Mousumi Sukul (University of Oslo)H-Index: 2
#2Priyanka Sahariah (RMIT: RMIT University)H-Index: 10
Last. Janne E. Reseland (University of Oslo)H-Index: 37
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Abstract We have studied the effect of chitosan sponges, produced from chitosan batches with distinct degree of deacetylation (DDA) and molecular weight (Mw), on the adhesion, growth and differentiation of primary human osteoblasts with an aim to offer a suitable tool for guided bone regeneration. All the chitosan sponges revealed similar microstructure, irrespective of the DDA (58, 73, 82, 88, and 91%) and Mw (749, 547, 263, 215, and 170 kDa, respectively). Cell spreading was higher on sponges ...
3 CitationsSource
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