Clinical and Hemodynamic Outcomes in 121 Patients Who Underwent Perceval Sutureless Aortic Valve Implantation - Early Results From a Single Korean Institution.

Published on Jun 25, 2021in Circulation23.603
· DOI :10.1253/CIRCJ.CJ-21-0023
Do Jung Kim3
Estimated H-index: 3
(Ajou University),
Sak Lee16
Estimated H-index: 16
(Yonsei University)
+ 3 AuthorsSeung-Hyun Lee21
Estimated H-index: 21
(Yonsei University)
BACKGROUND This study aimed to evaluate the early outcomes of Perceval sutureless valves in the Korean population and to introduce a modified technique of guiding suture placement during valve deployment.Methods and Results:From December 2014 to April 2019, 121 patients (mean age: 74.7±6.2 years; 53.7% female) received a Perceval sutureless aortic valve replacement. To prevent conduction system injury, the depth of guiding suture placement (1 mm below the nadir of the annulus) was modified. All patients underwent echocardiographic evaluation at discharge and 6-12 months postoperatively, with a mean follow up of 13.7±11.2 months. Concomitant surgeries, such as coronary artery bypass grafting, and other valvular surgeries, were performed in 45.5% of cases. The mean aortic cross-clamp times for isolated and minimal procedures were 32.8±7.9, and 41.2±8.0 min, respectively. The overall transvalvular mean gradients were 13.1±3.8 mmHg at discharge and 11.5±4.7 mmHg at the last follow up. After modifying the guiding suture placement, permanent pacemaker implantation risk decreased from 9.9% to 2.5%. Cardiac-related mortality was 0.8%, with no patient developing valvular or paravalvular aortic regurgitation, valve thrombosis, or endocarditis. CONCLUSIONS Perceval valve implantation provided a significant cardiac-related survival benefit with excellent early hemodynamic and clinical outcomes. Further research is needed to determine whether adjusting the implantation depth, such as modification of the guiding suture technique, can reduce the risk of permanent pacemaker implantation.
#1Kensuke Matsushita (UDS: University of Strasbourg)H-Index: 8
#2Mohamad Kanso (UDS: University of Strasbourg)H-Index: 3
Last. Patrick Ohlmann (UDS: University of Strasbourg)H-Index: 32
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BACKGROUND New-onset conduction abnormalities (CAs) following transcatheter aortic valve replacement (TAVR) are associated with hospital rehospitalization and long-term mortality, but available predictors are sparse. This study sought to determine clinical predictors of new-onset left bundle branch block (LBBB) and new permanent pacemaker (PPM) implantation in patients undergoing TAVR.Methods and Results:We enrolled 290 patients who received SAPIEN 3 (Edwards Lifesciences, Irvine, CA, USA; n=217...
3 CitationsSource
#1Ying-Hwa Chen (NYMU: National Yang-Ming University)H-Index: 16
#2Hsiao-Huang Chang (Taipei Veterans General Hospital)H-Index: 6
Last. Su-Man Lin (Taipei Veterans General Hospital)H-Index: 11
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#1Ferdinand VogtH-Index: 12
#2Marco MoscarelliH-Index: 13
Last. Giuseppe SantarpinoH-Index: 27
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Background Several studies reported high rates of postoperative permanent pacemaker (PPM) implantation, which has been described as the "Achilles' heel" of sutureless aortic valve replacement (AVR). Methods From July 2010 to December 2017, 3,158 patients with symptomatic, severe aortic valve stenosis were referred to the Department of Cardiac Surgery (Klinikum Nurnberg - Paraclesus Medical University, Nuremberg, Germany), and 512 received a Perceval sutureless bioprosthesis (LivaNova PLC, London...
13 CitationsSource
#1Sung Ho ShinnH-Index: 1
Last. Soon J. Park (Case Western Reserve University)H-Index: 64
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Background Sutureless aortic valve replacement (SU-AVR) and transcatheter aortic valve implantation (TAVI) are increasingly adopted methods to treat high-risk patients with severe aortic valve stenosis. We conducted a systematic review and meta-analysis to compare the clinical outcomes between these two recent methods to treat aortic valve disease. Methods We systematically searched multiple databases (January 2000 to October 2016) to identify original studies comparing clinical outcome between ...
8 CitationsSource
#1Çağdaş Baran (Ankara University)H-Index: 6
#2Mustafa Serkan Durdu (Ankara University)H-Index: 5
Last. Ahmet Rüçhan Akar (Ankara University)H-Index: 16
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Abstract Objectives Sutureless aortic valve replacement (SU-AVR) is an alternative technique to standard aortic valve replacement. We evaluated our experience with the Perceval SU-AVR with concomitant mitral valve surgery, with or without tricuspid valve surgery, and aimed to discuss the technical considerations. Methods From January 2013 through June 2016, 30 patients with concomitant severe mitral valve disease, with or without tricuspid valve disease, underwent SU-AVR with the Perceval prosth...
11 CitationsSource
#1Stephan Ensminger (RUB: Ruhr University Bochum)H-Index: 17
#2Buntaro Fujita (RUB: Ruhr University Bochum)H-Index: 15
Last. Christian FrerkerH-Index: 29
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Abstract Background Surgical aortic valve replacement using conventional biological valves (CBVs) is the standard of care for treatment of old patients with aortic valve disease. Recently, rapid deployment valves (RDVs) have been introduced. Objectives The purpose of this study was to report the nationwide German experience concerning RDVs for treatment of aortic valve stenosis and provide a head-to-head comparison with CBVs. Methods A total of 22,062 patients who underwent isolated surgical aor...
51 CitationsSource
#1Massimo MecoH-Index: 7
#2Antonio Miceli (UoB: University of Bristol)H-Index: 32
Last. Mattia GlauberH-Index: 35
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OBJECTIVES: The aim of this meta-analysis was to compare outcomes of patients undergoing transcatheter aortic valve implantation (TAVI) with those undergoing surgical aortic valve replacement using sutureless valves. METHODS: A systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was performed. RESULTS: No randomized controlled trials were identified. Six comparative studies using propensity score matchin...
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Background This study describes the clinical and echocardiographic outcomes in a large single-center cohort of patients who underwent aortic valve replacement (AVR) with a sutureless Perceval (LivaNova, Milan, Italy) aortic bioprosthesis. Methods Between March 2011 and December 2015, 617 patients underwent AVR with a Perceval bioprosthesis. The mean age was 76 ± 7 years, 388 patients were female (63%), and the mean European System for Cardiac Operative Risk Evaluation (EuroSCORE) II was 6.2% ± 5...
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#1Bobby Yanagawa (St. Michael's Hospital)H-Index: 30
#2Jorge Cruz (St. Michael's Hospital)H-Index: 4
Last. Daniel Bonneau (St. Michael's Hospital)H-Index: 11
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From the Division of Cardiac Surgery, St Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada. B.Y. and J.C. contributed equally. Disclosures: Authors have nothing to disclose with regard to commercial support. Received for publication Nov 30, 2015; revisions received Feb 5, 2016; accepted for publication Feb 16, 2016; available ahead of print March 10, 2016. Address for reprints: Daniel Bonneau, MD, Division of Cardiac Surgery, St Michael’s Hospital, 30 Bond St, 8th Floor, Bond W...
34 CitationsSource
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