Seung-Hyun Lee
Yonsei University
InkwellInternal medicineRadiologySurgeryArtificial intelligenceComposite materialCardiologyNanotechnologyElectrodeChemistryMaterials sciencePrinted electronicsAtrial fibrillationIn patientComputer scienceOptoelectronicsCancer researchMedicineNanowireBiologyThermal conductivity
Publications 262
#1Jaewon Oh (Yonsei University)H-Index: 19
#2Sun‐Ho Lee (Yonsei University)H-Index: 1
Last. Sahng Wook Park (Yonsei University)H-Index: 20
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Abstract null null Cardiac laminopathy caused by mutations in the LMNA gene are common and highly penetrant with a poor prognosis. We have generated a novel human induced pluripotent stem cell(iPSC) lines YCMi003-A from a patient with dilated cardiomyopathy associated with genetic variant LMNA c.1090G>C; p.Asp364His. We reprogrammed patient-specific peripheral blood mononuclear cells using five episomal vectors Oct4, Sox2, Lin28, L-Myc, and Klf4. The reported iPSC line would be a useful model fo...
#2Sang-ha LeeH-Index: 3
Last. Soonchul KwonH-Index: 6
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#1Do Jung Kim (Ajou University)H-Index: 3
#2Sak Lee (Yonsei University)H-Index: 16
Last. Seung-Hyun Lee (Yonsei University)H-Index: 21
view all 6 authors...
BACKGROUND This study aimed to evaluate the early outcomes of Perceval sutureless valves in the Korean population and to introduce a modified technique of guiding suture placement during valve deployment.Methods and Results:From December 2014 to April 2019, 121 patients (mean age: 74.7±6.2 years; 53.7% female) received a Perceval sutureless aortic valve replacement. To prevent conduction system injury, the depth of guiding suture placement (1 mm below the nadir of the annulus) was modified. All ...
1 CitationsSource
#1Jong Wook Song (Yonsei University)H-Index: 17
#2Sarah SohH-Index: 11
Last. Young Lan KwakH-Index: 32
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OBJECTIVES We investigated whether routine perioperative intravenous iron replenishment reduces the requirement for packed erythrocytes (pRBC) transfusion. SUMMARY BACKGROUND DATA Patients undergoing complex cardiac surgery are at high risk of developing postoperative iron deficiency anemia, thus requiring transfusion, which is associated with adverse outcomes. METHODS Patients were randomized to receive either ferric derisomaltose 20 mg/kg (n = 103) or placebo (n = 101) twice during the periope...
We present serial sonographic findings of a case of supraclavicular lymphadenopathy that occurred after COVID-19 vaccination. Ipsilateral lymphadenopathy near the vaccine injection site following COVID-19 vaccination is a rather uncommon but expected adverse reaction. While axillary lymphadenopathy is more common, cases of supraclavicular lymphadenopathy in the setting of recent vaccination against COVID-19 are also being reported. Radiologists as well as referring physicians should be aware of ...
#1Hyoeun Kim (Yonsei University)H-Index: 8
#2Dasom Mun (Yonsei University)H-Index: 7
Last. Boyoung Joung (Yonsei University)H-Index: 46
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Small extracellular vesicles (sEVs) are nanometer-sized membranous vesicles secreted by cells, with important roles in physiological and pathological processes. Recent research has established the application of sEVs as therapeutic vehicles in various conditions, including heart disease. However, the high risk of off-target effects is a major barrier for their introduction into the clinic. This study evaluated the use of modified sEVs expressing high levels of cardiac-targeting peptide (CTP) for...
#2Seung-Hyun LeeH-Index: 21
#3Helen LewH-Index: 12
#1Seung-Hyun Lee (Yonsei University)H-Index: 21
#2Namki Hong (Yonsei University)H-Index: 14
Last. Yumie Rhee (Yonsei University)H-Index: 32
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Pregnancy- and lactation-associated osteoporosis (PLO) is a rare and severe disorder that causes low-trauma or spontaneous fractures, most commonly multiple vertebral fractures, in the late pregnancy or lactation period [1]. In severe PLO, teriparatide (TPTD) might aid in bone mineral density (BMD) recovery and subsequent fracture risk reduction. However, it is unclear whether TPTD can be discontinued without sequential antiresorptive therapy (ART) in premenopausal women with PLO. In this retros...
#1Soo-Yeon Park (Yonsei University)H-Index: 11
#2Jung Yeon Hong (Yonsei University)H-Index: 11
Last. Ho-Geun Yoon (Yonsei University)H-Index: 35
view all 13 authors...
Idiopathic pulmonary fibrosis (IPF) causes progressive fibrosis and worsening pulmonary function. Prognosis is poor and no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression is increased in the lungs of patients with IPF and in mouse models of lung fibrosis. Lung fibrosis is significantly diminished by club cell-specific deletion of Pdcd5 gene. PDCD5 mediates β-catenin/Smad3 complex formation, promoting TGF-β-induced transcriptional activation of matricellular gen...
1 CitationsSource