Tau heckles speckles: A pathogenic mechanism in tauopathy?

Erica L. Gorenberg; James Shorter

doi:https://doi.org/10.1016/j.neuron.2021.04.022

doi.org/10.1016/j.neuron.2021.04.022

Tau heckles speckles: A pathogenic mechanism in tauopathy?

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Neuron16.20

Volume: 109, Issue: 10, Pages: 1585 - 1587

Published: May 1, 2021

Abstract

Protein aggregates can sequester RNA in neurodegenerative disease, but the exact RNAs sequestered by tau inclusions have remained uncharacterized. In this issue of Neuron, Lester et al., 2021Lester E. Ooi F.K. Bakkar N. Ayers J. Woerman A.L. Wheeler J. Bowser R. Carlson G.A. Prusiner S.B. Parker R. Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.Neuron. 2021; 109 (this issue): 1675-1691.e9Abstract...