Podophyllotoxin Exposure Affects Organelle Distribution and Functions in Mouse Oocyte Meiosis

Published on May 19, 2021in Frontiers in Cell and Developmental Biology5.201
· DOI :10.3389/FCELL.2021.672590
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#1Feifei Shi (NKU: Nankai University)H-Index: 1
#2Jinyu Qiu (NKU: Nankai University)H-Index: 1
Last. Xizeng Feng (NKU: Nankai University)H-Index: 20
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Abstract Decabromodiphenyl ethane (DBDPE), a widely used new brominated flame retardant, is added into flammable materials to achieve fire retardation. As it is continuously detected in the environment, it has become an emerging environmental pollutant. However, the effects of DBDPE exposure on oocyte maturation and its underlying mechanisms remain unknown. This study found that DBDPE exposure inhibited the rate of germinal vesicle breakdown (GVBD), first polar body extrusion (PBE) and fertiliza...
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#1Yue WangH-Index: 1
#2Shuhang WangH-Index: 1
Last. Xiangqun JinH-Index: 1
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Introduction Etoposide refers to a derivative of podophyllotoxin, which plays an important role in the treatment of cancer due to its prominent anti-tumor effect. As a BCS IV drug, etoposide exhibits insufficient aqueous solubility and permeability, thereby limiting its oral absorption. To enhance the oral bioavailability of etoposide, this study developed an amorphous nanopowder. Methods Based on preliminary screening and experimental design, the stabilizer and preparation process of etoposide ...
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#1Ah-Won Kwak (Mokpo National University)H-Index: 5
#2Goo Yoon (Mokpo National University)H-Index: 14
Last. Jung-Il ChaeH-Index: 20
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Esophageal squamous cell carcinoma (ESCC), a major histologic type of esophageal cancer, is one of the frequent causes of cancer-related death worldwide. Picropodophyllotoxin (PPT) is the main component of Podophyllum hexandrum root with antitumor activity via apoptosis-mediated mechanisms in several cancer cells. However, the underlying mechanism of the PPT effects in apoptosis induction in cancer remains ambiguous. Hence, in this study, we evaluate the anti-cancer effects of PPT in apoptotic s...
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#1Ming-Hong Sun (NAU: Nanjing Agricultural University)H-Index: 4
#2Xiao-Han Li (NAU: Nanjing Agricultural University)H-Index: 4
Last. Shao-Chen Sun (NAU: Nanjing Agricultural University)H-Index: 26
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Abstract Citrinin (CTN) is a secondary fungal metabolite produced by several species of Aspergillins and Penicillins, and it is widely found in vegetable-derived foods such as cereals and fermented rice-based food supplements. Previous studies indicated that CTN had immunotoxicity, hepatotoxicity, nephrotoxicity, and reproductive toxicity, which caused severe effects on human and animal health. However, the potential toxicity of CTN on the organelles of mouse oocytes is still unclear. In this st...
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#1Satoru Torii (Tokyo Medical and Dental University)H-Index: 16
#1Satoru Torii (Tokyo Medical and Dental University)H-Index: 4
Last. Shigeomi Shimizu (Tokyo Medical and Dental University)H-Index: 65
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Alternative autophagy is an autophagy-related protein 5 (Atg5)-independent type of macroautophagy. Unc51-like kinase 1 (Ulk1) is an essential initiator not only for Atg5-dependent canonical autophagy but also for alternative autophagy. However, the mechanism as to how Ulk1 differentially regulates both types of autophagy has remained unclear. In this study, we identify a phosphorylation site of Ulk1 at Ser746, which is phosphorylated during genotoxic stress-induced alternative autophagy. Phospho...
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#1Frédéric DariosH-Index: 28
#2Giovanni Stevanin (EPHE: École pratique des hautes études)H-Index: 79
Abstract Rare genetic diseases affect a limited number of patients, but their etiology is often known, facilitating the development of reliable animal models and giving the opportunity to investigate physiopathology. Lysosomal storage disorders are a group of rare diseases due to primary alteration of lysosome function. These diseases are often associated with neurological symptoms, which highlighted the importance of lysosome in neurodegeneration. Likewise, other groups of rare neurodegenerativ...
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#1Wen-Jie Jiang (Yanbian University)H-Index: 1
#2Lin-Lin HuH-Index: 1
Last. Yong-Nan Xu (Yanbian University)H-Index: 1
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Abstract Podophyllotoxin (PPT) is a lignan extracted from podophyllum genera and it shows potent antitumor activity since it could effectively inhibit the assembly of microtubule in tumor cells. However, the effects of podophyllotoxin exposure on porcine oocyte quality is still unclear. In present study we tried to examine whether podophyllotoxin exposure was toxic to porcine oocyte maturation. Our results showed that podophyllotoxin exposure inhibited porcine oocyte maturation, showing with the...
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#1Joyce C.M. Meiring (UU: Utrecht University)H-Index: 6
#2Boris I. Shneyer (UU: Utrecht University)H-Index: 1
Last. Anna Akhmanova (UU: Utrecht University)H-Index: 80
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Abstract Microtubules control cell architecture by serving as a scaffold for intracellular transport, signaling, and organelle positioning. Microtubules are intrinsically polarized, and their orientation, density, and post-translational modifications both respond and contribute to cell polarity. Animal cells that can rapidly reorient their polarity axis, such as fibroblasts, immune cells, and cancer cells, contain radially organized microtubule arrays anchored at the centrosome and the Golgi app...
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#1Qinghua Cui (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 7
#2Ruikun Du (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 10
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Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their ...
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#1Jia-Kun Miao (NEAU: Northeast Agricultural University)H-Index: 5
#2Yun-Hua Liu (NEAU: Northeast Agricultural University)H-Index: 5
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Abstract Lysosome, an important organelle in eukaryotes, can sequester macromolecules submitted by the endocytosis and autophagy pathways for degradation and recycling. Massive macromolecular turnover is also vital to the growth and development of mammalian oocytes. However, the functional role of lysosomes in the meiotic maturation of mammalian oocytes remains largely unexplored. Here, by treating in vitro matured porcine cumulus-oocyte complexes (COCs) with chloroquine (CQ), a lysosome inhibit...
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