Investigation on the Solubility of the Antidepressant Drug Escitalopram in Subcritical Water

Escitalopram (ESC), the S-enantiomer of citalopram, is a selective serotonin reuptake inhibitor. Escitalopram is widely used to treat panic disorder, depression, obsessive compulsive disorder, and social anxiety disorder. The main goal of this present research is to determine the aqueous solubility of ESC at temperatures ranging from 298 to 473 K and a pressure of 5.0 MPa. ESC solubility increased significantly from 1.08 × 10–3 to 59.88 × 10–3...