Original paper
UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling
Abstract
Type I/III IFNs induce expression of hundreds of IFN-stimulated genes through the JAK/STAT pathway to combat viral infections. Although JAK/STAT signaling is seemingly straightforward, it is nevertheless subjected to complex cellular regulation. In this study, we show that an ubiquitination regulatory X (UBX) domain-containing protein, UBXN6, positively regulates JAK-STAT1/2 signaling. Overexpression of UBXN6 enhanced type I/III IFNs–induced...
Paper Details
Title
UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling
Published Date
Jun 1, 2021
Journal
Volume
206
Issue
11
Pages
2682 - 2691
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Notes
History