The Colorectal Cancer Lipidome: Identification of a Robust Tumor-Specific Lipid Species Signature

Lipidomic changes were causally linked to metabolic diseases, but the scenario for colorectal cancer (CRC) is less clear. We investigated the CRC lipidome for putative tumor-specific alterations through analysis of 3 independent retrospective patient cohorts from 2 clinical centers, to derive a clinically useful signature.Quantitative comprehensive lipidomic analysis was performed using direct infusion electrospray ionization coupled with tandem...