Original paper
Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis
Abstract
Chronic myelogenous leukemia (CML) is a clonal malignancy of hematopoietic stem cells featured with the fusion protein kinase BCR-ABL. To elicit the mechanism underlying BCR-ABL stability, we perform a screen against a panel of deubiquitinating enzymes (DUBs) and find that the ubiquitin-specific protease 7 (USP7) drastically stabilizes the BCR-ABL fusion protein. Further studies show that USP7 interacts with BCR-ABL and blocks its...
Paper Details
Title
Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis
Published Date
May 7, 2021
Journal
Volume
12
Issue
5
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Notes
History