Circulating vitamin C and the risk of cardiovascular diseases: A Mendelian randomization study

Background and aims The impact of vitamin C supplementation on the risk of cardiovascular diseases (CVDs) remains uncertain with inconsistent evidence obtained from observational studies and randomized clinical trials (RCTs). We aimed to assess possible causal associations of vitamin C with major CVD events as well as their risk factors using Mendelian randomization (MR) design. Methods and results Nine genetic variants associated with vitamin C...