SMARCA2 Deficiency While Preserving SMARCA4 and SMARCB1 in Lung Neuroendocrine Carcinomas

The human BAF multiprotein complex of adenosine triphosphate-dependent nucleosome remodeler (mammalian SWItch/sucrose nonfermentable) regulates gene expression, cell proliferation and cell differentiation by tuning transcription factor access to chromatin. It is composed of about 15 high-evolutionarily conserved proteins, which are involved in approximately 20% of life-threatening malignancies at ubiquitous sites. In the thoracic domain,...