Adverse immunological responses against non-viral nanoparticle (NP) delivery systems in the lung.
Abstract
There is a large, unmet medical need to treat chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis and other respiratory diseases. New modalities are being developed, including gene therapy which treats the disease at the DNA/RNA level. Despite recent innovations in non-viral gene therapy delivery for chronic respiratory diseases, unwanted or adverse interactions with immune cells, particularly macrophages, can limit drug...
Paper Details
Title
Adverse immunological responses against non-viral nanoparticle (NP) delivery systems in the lung.
Published Date
May 6, 2021
Journal
Volume
18
Issue
1
Pages
61 - 73
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Notes
History