Journal of Immunotoxicology
IF
3.00
Papers
721
Papers 721
1 page of 73 pages (721 results)
#1Wenhua Zhong (HMU: Hainan Medical University)
#2Penghuan Chang (Haikou City People's Hospital)
Last. Zhaoxin Yang (HMU: Hainan Medical University)
view all 5 authors...
Most current methods to assess T-cell-dependent antibody responses (TDAR) are semi-quantitative and based on measures of antibody titer generated against a standard antigen like keyhole limpet hemocyanin (KLH). The precision, sensitivity, and convenience of TDAR assays might be improved by applying rapid, sensitive, specific cytometric bead assays (CBA). In the study here, KLH antigen was covalently coupled onto the surface of cytometric beads using immune microsphere technology, and IgM antibod...
Source
#1Yang Qu (Liaocheng People's Hospital)
#2Lin Wang (Liaocheng People's Hospital)
Last. Yanfang Mao (Liaocheng People's Hospital)
view all 3 authors...
Microglia, the main immune effector cells in the central nervous system, play a dual role in the function/structure of the blood-brain barrier (BBB) and brain health. During and soon after a cerebral ischemic injury, microglia produce neurotrophic factors and neurotoxins that can impact on the injury itself and pathology progression. At the same time, microglia undergo polarization to M1 or M2 pro- vs. anti-inflammatory subtypes that also help drive the outcome of the injury process. Thus, agent...
Source
#1Shraddha S Rane (MAHSC: Manchester Academic Health Science Centre)
#2Rebecca J Dearman (MAHSC: Manchester Academic Health Science Centre)
Last. Jeremy P Derrick (MAHSC: Manchester Academic Health Science Centre)
view all 4 authors...
Biotherapeutic monoclonal antibodies (mAb) play important roles in clinical medicine but their potential to elicit immune responses in patients remains a major issue. In a study designed to investigate the effect of aggregation on immunogenic responses, mice were immunized with two monoclonal antibodies (mAb1 and mAb2). Serum levels of total IgG, IgG1, and IgG2a were measured by ELISA. An anti-mouse IgG2a monoclonal detection antibody cross-reacted with mAb2 but not mAb1, leading to high backgro...
Source
#1Ryutaro Nishioka (Ehime University)
#2Yusuke Nishi (Ehime University)
Last. Junya Tanaka (Ehime University)H-Index: 40
view all 11 authors...
Sepsis is a pathology accompanied by increases in myeloid cells and decreases in lymphoid cells in circulation. In a murine sepsis model induced by cecum ligation and puncture (CLP), increasing numbers of neutrophils and decreasing levels of B-cells in circulation are among the earliest changes in the immune system. However, to date, the mechanisms for these changes remain to be elucidated. The study here sought to elucidate mechanisms underlying the changes in the leukocyte levels after CLP and...
Source
#1Akira Ogasawara (Kao Corporation)
#2Takuo Yuki (Kao Corporation)
Last. Hitoshi Sakaguchi (Kao Corporation)
view all 7 authors...
Epicutaneous exposure to protein allergens, such as papain, house dust mite (HDM), and ovalbumin (OVA), represents an important mode of sensitization for skin diseases including protein contact dermatitis, immunologic contact urticaria, and atopic dermatitis. These diseases are inducible by re-exposure to an allergen at both original skin sensitization and distant skin sites. In this study, we examined the serum IgE/IgG1 response, differentiation of T-helper (TH) cells, and epicutaneous TH recal...
Source
#1Ryutaro Nishioka (Ehime University)
#2Yusuke Nishi (Ehime University)
Last. Junya Tanaka (Ehime University)H-Index: 40
view all 11 authors...
Sepsis is a pathology accompanied by increases in myeloid cells and decreases in lymphoid cells in circulation. In a murine sepsis model induced by cecum ligation and puncture (CLP), increasing numbers of neutrophils and decreasing levels of B-cells in circulation are among the earliest changes in the immune system. However, to date, the mechanisms for these changes remain to be elucidated. The study here sought to elucidate mechanisms underlying the changes in the leukocyte levels after CLP and...
Source
#1Ryutaro Nishioka (Ehime University)
#2Yusuke Nishi (Ehime University)
Last. Junya Tanaka (Ehime University)H-Index: 40
view all 11 authors...
Sepsis is a pathology accompanied by increases in myeloid cells and decreases in lymphoid cells in circulation. In a murine sepsis model induced by cecum ligation and puncture (CLP), increasing numbers of neutrophils and decreasing levels of B-cells in circulation are among the earliest changes in the immune system. However, to date, the mechanisms for these changes remain to be elucidated. The study here sought to elucidate mechanisms underlying the changes in the leukocyte levels after CLP and...
Source
#1Yang Qu (Liaocheng People's Hospital)
#2Lin Wang (Liaocheng People's Hospital)
Last. Yanfang Mao (Liaocheng People's Hospital)
view all 3 authors...
Microglia, the main immune effector cells in the central nervous system, play a dual role in the function/structure of the blood-brain barrier (BBB) and brain health. During and soon after a cerebral ischemic injury, microglia produce neurotrophic factors and neurotoxins that can impact on the injury itself and pathology progression. At the same time, microglia undergo polarization to M1 or M2 pro- vs. anti-inflammatory subtypes that also help drive the outcome of the injury process. Thus, agent...
Source
#1Junya Tanaka (Ehime University)H-Index: 40
Sepsis is a pathology accompanied by increases in myeloid cells and decreases in lymphoid cells in circulation. In a murine sepsis model induced by cecum ligation and puncture (CLP), increasing numbers of neutrophils and decreasing levels of B-cells in circulation are among the earliest changes in the immune system. However, to date, the mechanisms for these changes remain to be elucidated. The study here sought to elucidate mechanisms underlying the changes in the leukocyte levels after CLP and...
Source
#1Fangyi Yao (First Affiliated Hospital of Nanchang University)
#2Chuxin Xu (First Affiliated Hospital of Nanchang University)
Last. Qing Luo (First Affiliated Hospital of Nanchang University)
view all 10 authors...
As an important m6A reader, the YT521-B homology domain family 2 (YTHDF2) has been shown to regulate mRNA degradation and translation, and to be involved in inflammation. However, little is known about the role of YTHDF2 in the autoimmune-based inflammatory disease rheumatoid arthritis (RA). To begin to ascertain any role for this reader, 74 RA patients and 63 healthy controls (HC) were recruited for this study. Blood was collected from each subject and peripheral blood mononuclear cells (PBMC) ...
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