Original paper
Applications of Mechanochemistry for the Synthesis of DNA on Ionic Liquid Supports
Abstract
The standard methodology for the synthesis of oligonucleotides is the solid‐phase method. Here, we report the first case of mechanochemistry being directly applied to synthesising a dinucleotide on a soluble support. While mechanochemistry eliminates the need to solubilise a supported oligomer in the solution phase for phosphoramidite coupling, the support still confers the benefit of being able to purify the product by precipitation or by...
Paper Details
Title
Applications of Mechanochemistry for the Synthesis of DNA on Ionic Liquid Supports
Published Date
May 5, 2021
Journal
Volume
1
Issue
8
Pages
382 - 388
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Notes
History