Induction of alopecia areata in C3H/HeJ mice using cryopreserved lymphocytes

BackgroundAlopecia areata (AA) is an autoimmune disease resulting in non-scarring hair loss. Animal models are useful means to identify candidates for therapeutic agents. The C3H/HeJ mouse AA model induced via transferring cultured lymphoid cells isolated from AA-affected mice is widely used for AA research. However, this conventional method requires the continuous breeding of AA mice.ObjectiveWe aimed to establish a new method to generate AA...