Effects of Real-Ambient PM2.5 Exposure on Lung Damage Modulated by Nrf2−/−

Previous studies have shown that long-term exposure to fine particulate matter (PM 2.5 ) increases the morbidity and mortality of pulmonary diseases such as asthma, chronic obstructive pulmonary disease and pulmonary emphysema. Oxidative stress and inflammation play key roles in pulmonary damage caused by PM 2.5 . Nuclear factor erythroid 2-related factor 2 (Nrf2) could regulate the expression of antioxidant and anti-inflammatory genes and is...