Frontiers in Pharmacology
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#1Yueming ZhangH-Index: 1
Last. Jian ZhangH-Index: 149
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Urothelial cancer (UC) is one of the common refractory tumors and chemotherapy is the primary treatment for it. The advent of immune checkpoint inhibitors (ICI) has facilitated the development of treatment strategies for UC patients. To screen out UC patients sensitive to ICI, researchers have proposed that PD-L1, tumor mutation burden and TCGA molecular subtypes can be used as predictors of ICI efficacy. However, the performance of these predictors needs further validation. We need to identify ...
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#1Ying LiH-Index: 1
Last. Bikui ZhangH-Index: 16
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Currently, polymyxin B has been widely used in the treatment of multidrug-resistant gram-negative pathogen infections. Due to the limited pharmacokinetic/pharmacodynamic data, the optimal dosage regimen for the recently proposed therapeutic target of the area under the concentration-time curve over 24 h in steady state divided by the minimum inhibitory concentration 50-100 mg·h/L has not yet been established. Moreover, most studies have focused on critically ill patients, yet there have been no ...
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#1Dongling LiuH-Index: 3
#2Xiang ZengH-Index: 2
Last. Xianwei WangH-Index: 28
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Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 infection is the cause of the ongoing global pandemic. Mortality from COVID-19 infection is particularly high in patients with cardiovascular diseases. In addition, COVID-19 patients with preexisting cardiovascular comorbidities have a higher risk of death. Main cardiovascular complications of COVID-19 are myocardial infarction, myocarditis, acute myocardial injury, arrhythmias, heart failure, stroke, and venous th...
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#1Alireza TafazoliH-Index: 6
#2Henk-Jan GuchelaarH-Index: 74
Last. Jesse J. SwenH-Index: 29
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Pharmacogenomics (PGx) studies the use of genetic data to optimize drug therapy. Numerous clinical centers have commenced implementing pharmacogenetic tests in clinical routines. Next-Generation Sequencing (NGS) technologies are emerging as a more comprehensive and time and cost-effective approach in PGx. This review presents main considerations for applying NGS in guiding drug treatment in clinical practice. It discusses both advantages and challenges of implementing NGS-based tests in PGx. Mor...
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#1Godwin AnywarH-Index: 7
#2Muhammad AkramH-Index: 31
Last. Muhammad Amjad ChishtiH-Index: 2
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Introduction: The worldwide burden of viral infection has triggered a resurgence into the search for new and more efficient antiviral medicines. Scientists are also repurposing existing natural compounds as potential drug candidates for of the emerging and re-emerging viral infections especially Aim: The aim of this mini review was to analyse the existing literature to explore actual or potential natural antiviral compounds from plants as lead compounds in the drug discovery process. Methods: We...
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Plant polyphenols have promoting health features, including anti-mutagenic, anti-inflammatory, anti-thrombotic, anti-atherogenic, and anti-allergic effects. These polyphenols improve the immune system by affecting the white blood cell proliferation, as well as by the synthesis of cytokines and other factors, which contribute to immunological resistance. Olive trees are one of the most famous trees in the world. Whereas, olive olive oil and derivatives represent a large group of feeding resource ...
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Cancer has become the second greatest cause of death worldwide. Although there are several different classes of anticancer drugs that are available in clinic, some tough issues like side-effects and low efficacy still need to dissolve. Therefore, there remains an urgent need to discover and develop more effective anticancer drugs. MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs that regulate gene expression by inhibiting mRNA translation or reducing the stability of mRNA. An a...
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#1Jia-Zhen WuH-Index: 9
#2Yuxuan GanH-Index: 4
Last. Jian-Hui XieH-Index: 21
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Intestinal mucositis (IM) is the main side effect observed in patients who receive cancer chemotherapy. The characteristics of ulceration, vomiting, and severe diarrhea cause patients to delay or abandon further treatment, thereby aggravating their progress. Hence, IM cannot be overlooked. β-patchoulene (β-PAE) is an active ingredient isolated from Pogostemon cablin (Blanco) Benth. (Labiatae) and has shown a marked protective effect against gastrointestinal diseases in previous studies. However,...
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