Antitumor and antimigration effects of Salvia clandestina L. extract on osteosarcoma cells

Salvia clandestina L. is a wild perennial species present in the Salento area of Italy. Here, we examined the in vitro effects of an aqueous extract of S. clandestina L. on the MG-63 osteosarcoma cell line. The extract reduced osteosarcoma cell viability mainly by way of apoptosis, as we observed (1) upregulation of gene and protein expression of p53, cyclin-dependent kinase inhibitors p21WAF1 and p27Kip1 , and proapoptotic BAX; (2) activation...