Original paper

Aging Modulates the Effects of Ischemic Injury Upon Mesenchymal Cells within the Renal Interstitium and Microvasculature

Volume: 10, Issue: 8, Pages: 1232 - 1248
Published: May 5, 2021
Abstract
The renal mesenchyme contains heterogeneous cells, including interstitial fibroblasts and pericytes, with key roles in wound healing. Although healing is impaired in aged kidneys, the effect of age and injury on the mesenchyme remains poorly understood. We characterized renal mesenchymal cell heterogeneity in young vs old animals and after ischemia-reperfusion-injury (IRI) using multiplex immunolabeling and single cell transcriptomics....
Paper Details
Title
Aging Modulates the Effects of Ischemic Injury Upon Mesenchymal Cells within the Renal Interstitium and Microvasculature
Published Date
May 5, 2021
Volume
10
Issue
8
Pages
1232 - 1248
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