Stem Cells Translational Medicine
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6.43
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1327
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#1Gary M. Green (Wake Forest Institute for Regenerative Medicine)
#2Russ H. Read (Forsyth Technical Community College)
Last. Anthony Atala (Wake Forest Institute for Regenerative Medicine)H-Index: 140
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In its 2019 report, The Skilled Technical Workforce: Crafting America's Science and Engineering Enterprise, the National Science Board recommended a national charge to create a skilled technical workforce (STW) driven by science and engineering. The RegenMed Development Organization (ReMDO), through its RegeneratOR Workforce Development Initiative, has taken on this challenge beginning with an assessment of regenerative medicine (RM) biomanufacturing knowledge, skills, and abilities (KSAs) neede...
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#1Han-Sol So (CBNU: Chonbuk National University)H-Index: 1
#2Min-Guk Kim (CBNU: Chonbuk National University)
Last. Sung-Ho Kook (CBNU: Chonbuk National University)H-Index: 21
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Hematopoietic stem progenitor cells (HSPCs) mobilized to peripheral blood, rather than those remaining in the bone marrow (BM), are commonly used as stem cell source in the clinic. As reactive oxygen species (ROS) are suggested as mediator of HSPC mobilization, we examined the impacts of glucose oxidase (GO) on peripheral mobilization of BM HSPCs and the associated mechanisms. Intravenous injection of GO induced HSPC mobilization even by single treatment, and the GO-mobilized cells maintained th...
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#1José Becerra (UMA: University of Málaga)H-Index: 26
#2Ivan Duran (UMA: University of Málaga)H-Index: 16
As our life expectancy increases, specific medical conditions appear, and new challenges are met in terms of global health. Frailty has become a medical and scientific concept to define pathologies where inflammation, depressed immune system, cellular senescence, and molecular aging converge. But more importantly, frailty is the ultimate cause of death that limits our life span and deteriorates health in an increasing proportion of the world population. The difficulty of tackling this problem is...
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#1Nicholas Stone (Georgia Institute of Technology)H-Index: 3
#2Andrew P. Voigt (Roy J. and Lucille A. Carver College of Medicine)H-Index: 9
Last. Budd A. Tucker (Roy J. and Lucille A. Carver College of Medicine)H-Index: 40
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Autologous photoreceptor cell replacement is one of the most promising approaches currently under development for the treatment of inherited retinal degenerative blindness. Unlike endogenous stem cell populations, induced pluripotent stem cells (iPSCs) can be differentiated into both rod and cone photoreceptors in high numbers, making them ideal for this application. That said, in addition to photoreceptor cells, state of the art retinal differentiation protocols give rise to all of the differen...
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#1La Tonya J. Hickson (Mayo Clinic)H-Index: 21
#2Tala Abedalqader (Mayo Clinic)
Last. Elizabeth C. Lorenz (Mayo Clinic)H-Index: 20
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Regenerative, cell-based therapy is a promising treatment option for diabetic kidney disease (DKD), which has no cure. To prepare for clinical translation, this systematic review and meta-analysis summarized the effect of cell-based interventions in DKD animal models and treatment-related factors modifying outcomes. Electronic databases were searched for original investigations applying cell-based therapy in diabetic animals with kidney endpoints (January 1998-May 2019). Weighted or standardized...
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#1Ismail Hadisoebroto Dilogo (UI: University of Indonesia)H-Index: 6
#2Dita Aditianingsih (UI: University of Indonesia)H-Index: 7
Last. Tera Kispa (UI: University of Indonesia)H-Index: 1
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One of the main causes of acute respiratory distress syndrome in coronavirus disease 2019 (COVID-19) is cytokine storm, although the exact cause is still unknown null Umbilical cord mesenchymal stromal cells (UC-MSCs) influence proinflammatory T-helper 2 (Th(2) ) cells to shift to an anti-inflammatory agent null To investigate efficacy of UC-MSC administration as adjuvant therapy in critically ill patients with COVID-19, we conducted a double-blind, multicentered, randomized controlled trial at ...
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#1Sabrina Lin (UCR: University of California, Riverside)H-Index: 14
#2Antonio Loza (UCR: University of California, Riverside)H-Index: 1
Last. Prue Talbot (UCR: University of California, Riverside)H-Index: 44
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StemCellQC is a video bioinformatics software tool for the quantitative analysis of human pluripotent stem cell (hPSC) colonies. Our objective was to use StemCellQC to evaluate and compare various experimental culture conditions, cell lines, and treatments and to demonstrate its applicability to PSC problems. Seven key features were identified that provided useful information on PSC morphology, dynamic behavior, and viability. Colony attachment was better on laminin-521 than on Matrigel and Gelt...
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#1Jessica Sun (Duke University)H-Index: 12
#2Laura E. Case (Duke University)H-Index: 25
Last. Joanne Kurtzberg (Duke University)H-Index: 99
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Preclinical and early phase clinical studies suggest that an appropriately dosed umbilical cord blood (CB) infusion has the potential to help improve motor function in young children with cerebral palsy (CP). As many children with CP do not have their own CB available, use of allogeneic cells would extend access to this potentially beneficial therapy to more children. In this phase I, open-label study, 15 children, aged 1 to 6 years, with moderate to severe spastic CP were treated with a single ...
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#1Liem NguyenH-Index: 4
#2Duc M. HoangH-Index: 1
Last. Anh Viet BuiH-Index: 1
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Human bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) represent promising stem cell therapy for the treatment of type 2 diabetes mellitus (T2DM), but the results of autologous BM-MSC administration in T2DM patients are contradictory. The purpose of this study was to test the hypothesis that autologous BM-MSC administration in T2DM patient is safe and that the efficacy of the treatment is dependant on the quality of the autologous BM-MSC population and administration routes. T2DM pat...
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Top fields of study
Induced pluripotent stem cell
Mesenchymal stem cell
Immunology
Stem cell
Medicine
Biology
Cell biology