Elderly patients with comorbidities in the definition of difficult-to-treat rheumatoid arthritis

The advent of biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) has improved the management of rheumatoid arthritis (RA) dramatically. However, there are patients who have not been controlled adequately, and EULAR has recently proposed a definition of difficult-to-treat RA (D2T RA).1 We have verified the definition in our institution, where approximately 60% of 1700 patients with RA have been treated with...