Tsutomu Takeuchi
Keio University
Internal medicineSurgeryPathologyMolecular biologyAntibodyAdverse effectRheumatologyImmunologyPlaceboArthritisInfliximabTocilizumabRheumatoid arthritisDiseasePathogenesisMethotrexateIn patientMedicineBiologyGastroenterology
839Publications
84H-index
24kCitations
Publications 825
Newest
#1Masaru Takeshita (Keio: Keio University)H-Index: 8
#2Katsuya Suzuki (Keio: Keio University)H-Index: 21
Last. Tsutomu Takeuchi (Keio: Keio University)H-Index: 84
view all 8 authors...
Abstract Interstitial lung disease (ILD) sometimes becomes a life-threatening complication of systemic autoimmune diseases; however, little is known about the immune response in lung lesions. We aimed to investigate humoural immunity in ILD associated with rheumatoid arthritis (RA), sjogren's syndrome (SjS), and mixed connective tissue disease (MCTD), using bronchoalveolar fluid (BALF) and serum samples from 15 patients with autoimmune disease associated-ILD. We first showed that BALF contained ...
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#1Peter C. TaylorH-Index: 69
#2B. DownieH-Index: 1
Last. Tsutomu TakeuchiH-Index: 84
view all 6 authors...
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#1Kunihiro Yamaoka (Kitasato University)H-Index: 20
#2Yoshiya TanakaH-Index: 92
Last. Tsutomu Takeuchi (Keio: Keio University)H-Index: 84
view all 9 authors...
INTRODUCTION Upadacitinib is a Janus kinase inhibitor with demonstrated efficacy in patients with rheumatoid arthritis (RA). OBJECTIVE The aim of this study was to assess the long-term safety of upadacitinib in patients with active RA from Japan compared with global clinical trial populations. METHODS Pooled data in patients enrolled from Japan (the 'Japanese population'; SELECT-SUNRISE, SELECT-EARLY, and SELECT-MONOTHERAPY) were compared with that from global (Japan and ex-Japan) upadacitinib c...
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#1Hironari HanaokaH-Index: 7
#2Jun KikuchiH-Index: 5
Last. Tsutomu TakeuchiH-Index: 84
view all 7 authors...
Background: Low levels of serum magnesium perturb renal tubular cell function and lymphocytes, resulting in renal deterioration and an imbalance in mononuclear cells. This study investigated the mechanism and influence of hypomagnesemia in patients with connective tissue disease. Methods: We retrospectively evaluated patients with connective tissue disease and available serum magnesium data who visited Keio University Hospital in 2019. Patients were divided into two groups: those with (serum mag...
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#1Satoshi Takanashi (Keio: Keio University)H-Index: 5
#2Yuko Kaneko (Keio: Keio University)H-Index: 20
Last. Tsutomu Takeuchi (Keio: Keio University)H-Index: 84
view all 3 authors...
The advent of biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) has improved the management of rheumatoid arthritis (RA) dramatically. However, there are patients who have not been controlled adequately, and EULAR has recently proposed a definition of difficult-to-treat RA (D2T RA).1 We have verified the definition in our institution, where approximately 60% of 1700 patients with RA have been treated with b/tsDMARDs based on the EULAR recommendation and treat-...
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#1Kotaro Matsumoto (Keio: Keio University)H-Index: 4
#2Takahiko Kurasawa (Keio: Keio University)H-Index: 8
Last. Tsutomu Takeuchi (Keio: Keio University)H-Index: 84
view all 5 authors...
BACKGROUND Leukocyte activation by anti-neutrophil cytoplasmic antibody (ANCA) and the subsequent leukocyte-endothelium interaction play a key role in the development of endothelial damage in ANCA-associated vasculitis (AAV). In contrast to that of leukocyte activation, the exact role of the leukocyte-endothelium interaction via integrin remains unclear. Here, we performed microarray and validation analyses to explore association between the expression levels of lymphocyte function-associated an...
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#1Tsutomu Takeuchi (Keio: Keio University)H-Index: 84
#2Yoshiya TanakaH-Index: 92
Last. Daisuke Kato (Astellas Pharma)
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To evaluate the safety of peficitinib for the treatment of rheumatoid arthritis (RA) in Asian patients. Safety data from one Phase 2b, two Phase 3, and one open-label long-term extension study [dat...
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#1Yasushi Kondo (Keio: Keio University)H-Index: 6
#2Yuko Kaneko (Keio: Keio University)H-Index: 20
Last. Tsutomu Takeuchi (Keio: Keio University)H-Index: 84
view all 11 authors...
We read the article regarding COVID-19 in patients with systemic lupus erythematosus (SLE) by Mathian et al 1 with great interest. We would like to report a case with SLE with COVID-19 who presented severe relapse of thrombocytopaenia. Mild thrombocytopaenia during COVID-19 is frequently observed, and immune thrombocytopaenia (ITP) has also been reported.2 3 Management of ITP during active COVID-19 can be difficult as immunosuppressive therapies can exacerbate infections, and the recovery of pla...
10 CitationsSource
#1Xianyong YinH-Index: 26
#1Xianyong YinH-Index: 1
Last. Sang Cheol Bae (Hanyang University)H-Index: 89
view all 87 authors...
Objective Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain SLE heritability and their putative causal variants are rarely prioritised, which make challenging to elucidate disease biology. To detect new SLE loci and causal variants, we performed the largest genome-wide meta-analysis for SLE in East Asian populations. Methods We newly genotyped 10 029 SLE cases and 180 167 controls a...
8 CitationsSource
#1Nobuhiko Kajio (Keio: Keio University)
#2Masaru Takeshita (Keio: Keio University)H-Index: 8
Last. Tsutomu Takeuchi (Keio: Keio University)H-Index: 84
view all 11 authors...
Objectives Anti-centromere antibodies (ACAs) are detected in patients with various autoimmune diseases such as Sjogren’s syndrome (SS), systemic sclerosis (SSc) and primary biliary cholangitis (PBC). However, the targeted antigens of ACAs are not fully elucidated despite the accumulating understanding of the molecular structure of the centromere. The aim of this study was to comprehensively reveal the autoantigenicity of centromere proteins. Methods A centromere antigen library including 16 prin...
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