Emerging Technologies for Microbiologic Diagnosis of Sepsis: The Rapid Determination of Resistance to Antimicrobial Agents Should Be the Key

(See the Major Article by Fida et al on pages 1165–72.) Blood cultures (BCs), aiming at the detection of viable microorganisms in blood, are currently considered the gold standard for microbiological diagnosis of bloodstream infections (BSIs) during sepsis [1]. However, this culture-based diagnosis suffers from important limitations, such as the long time to positivity (usually from 12 to 72 hours), the false-negative results due to ongoing...