Enhanced radiotherapy efficacy and induced anti-tumor immunity in HCC by improving hypoxia microenvironment using oxygen microcapsules

Hypoxia represents a tremendous barrier for effective radiotherapy in hepatocellular carcinoma (HCC). Treatment strategies for improving hypoxia are of great significance to enhance radiotherapy efficacy. Here, we design polydopamine-nanoparticle-stabilized oxygen microcapsules by interfacial polymerization, which encapsulate oxygen in the core of polydopamine nanoparticle shell, exhibiting excellent biocompatibility and dispersity in aqueous...