Original paper
SCAMP3 is a mutant EGFR phosphorylation target and a tumor suppressor in lung adenocarcinoma
Abstract
Mutations in the epidermal growth factor receptor (EGFR) tyrosine kinase domain constitutively activate EGFR resulting in lung tumorigenesis. Activated EGFR modulates downstream signaling by altering phosphorylation-driven interactions that promote growth and survival. Secretory carrier membrane proteins (SCAMPs) are a family of transmembrane proteins that regulate recycling of receptor proteins, including EGFR. The potential role of SCAMPs in...
Paper Details
Title
SCAMP3 is a mutant EGFR phosphorylation target and a tumor suppressor in lung adenocarcinoma
Published Date
Apr 13, 2021
Journal
Volume
40
Issue
18
Pages
3331 - 3346
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Notes
History