The long noncoding RNA lnc-HLX-2-7 is oncogenic in Group 3 medulloblastomas

Medulloblastoma (MB) is an aggressive brain tumor that predominantly affects children. Recent high-throughput sequencing studies suggest that the noncoding RNA genome, in particular long noncoding RNAs (lncRNAs), contributes to MB subgrouping. Here we report the identification of a novel lncRNA, lnc-HLX-2-7, as a potential molecular marker and therapeutic target in Group 3 MBs.Publicly available RNA sequencing (RNA-seq) data from 175 MB patients...