Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study.

Published on Apr 11, 2021in Multiple sclerosis and related disorders4.339
路 DOI :10.1016/J.MSARD.2021.102947
Mahdi Barzegar8
Estimated H-index: 8
(IUMS: Isfahan University of Medical Sciences),
Saeed Vaheb5
Estimated H-index: 5
(IUMS: Isfahan University of Medical Sciences)
+ 3 AuthorsVahid Shaygannejad25
Estimated H-index: 25
(IUMS: Isfahan University of Medical Sciences)
Abstract The effect of coronavirus disease (COVID-19) on the risk of relapse in multiple sclerosis (MS) have been unknown. In this retrospective study of 41 relapsing-remitting MS patients, number of relapses in pre-defined at risk-period (ARP) was compared with the previous two years. During the previous two years, a total of 32 attacks was reported, which 5 (15.6%) were during the at-risk period. After adjusting for age and sex, there was an increased risk of attack during ARP compared to the previous two years (RR: 2.566, 95%CI: 1.075-6.124, P=0.034). Our preliminary study suggested that COVID-19 can trigger exacerbation of MS.
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