Circulating PTHrP measurement in the assessment of severe hypercalcaemia in an infant.

Published on Apr 15, 2021in Journal of Clinical Pathology2.46
· DOI :10.1136/JCLINPATH-2021-207390
Mark Kilbane13
Estimated H-index: 13
(UCD: University College Dublin),
Rachel K Crowley17
Estimated H-index: 17
+ 2 AuthorsPatrick J Twomey22
Estimated H-index: 22
Sources
Abstract
Parathyroid hormone-related protein (PTHrP) can simulate most of the actions of parathyroid hormone (PTH) including increases in bone resorption and distal tubular calcium reabsorption and inhibition of proximal tubular phosphate transport.1 The low serum phosphate in parallel with low circulating PTH is consistent with PTHrP involvement in this case. Whether it can be causative for a serum calcium of 6.24 mmol/L however is a moot point. While the mechanism underlying the patient’s severe hypercalcaemia proposed by the authors is plausible, the evidence provided for PTHrP being at the root cause is not definitive. The significant differences in mRNA and PTHrP protein fragments reported between neoplastic and normal tissue does not inform on its functional status; it could be …
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