Paeonol-loaded PLGA nanoparticles as an oral drug delivery system: Design, optimization and evaluation
Abstract
Herein, we report a novel type of NPs by loading paeonol (Pae) into PLGA NPs, to enhance drug stability and oral bioavailability. The paeonol (Pae)-loaded polylactic-co-Gly-colic acid (PLGA) nanoparticles (Pae-PLGA-NPs) were prepared by nanoprecipitation method. The resultant NPs were in spherical shape with an average particle size around 237.7 ± 4.92 nm, and the PDI and zeta potential were 0.110 ± 0.01 and −25.33 ± 1.37 mV, respectively. The...
Paper Details
Title
Paeonol-loaded PLGA nanoparticles as an oral drug delivery system: Design, optimization and evaluation
Published Date
Jun 1, 2021
Volume
602
Pages
120617 - 120617
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