International Journal of Pharmaceutics
IF
4.84
Papers
19360
Papers 10000
1 page of 1,000 pages (10k results)
Newest
#1Jonas Rudén (Uppsala University)H-Index: 2
#2Göran Frenning (Uppsala University)H-Index: 19
Last. Göran Alderborn (Uppsala University)H-Index: 39
view all 5 authors...
Abstract The objectives of this investigation were to study the evolution in blend state of adhesive mixtures containing the active pharmaceutical ingredients (APIs) salbutamol, budesonide and AZD5423 and to study the relationship between blend state and dispersibility of the mixtures, as assessed by the fine particle fraction (FPF). A series of adhesive mixtures of varied fines concentration were prepared for each API using the same type of carrier. Based on visual examination and powder mechan...
Source
#1Sonja Schertel (University of Graz)
#2Sharareh Salar-Behzadi (University of Graz)H-Index: 2
Last. Andreas Zimmer (University of Graz)H-Index: 15
view all 5 authors...
Abstract null null Hydrochlorothiazide (HCT) multiparticulate systems (MPS) were hot melt coated with the binary mixture of tripalmitin (PPP) and polysorbate 65 (PS 65) to gain an immediate release profile. Once, HCT MPS were produced with a constant ratio of PPP/PS 65 (90:10) at three different coating amounts (15, 25, and 60%w/w) and once the PPP/PS 65 ratio was varied on 98:2 and 80:20, by keeping the coating amount at 60%w/w. PS 65 induced the polymorphic transformation of PPP from the α-for...
Source
#1Usri H. Ibrahim (UKZN: University of KwaZulu-Natal)H-Index: 1
#2Nikita Devnarain (UKZN: University of KwaZulu-Natal)H-Index: 4
Last. Thirumala Govender (UKZN: University of KwaZulu-Natal)H-Index: 30
view all 5 authors...
Abstract null null In this study, ascorbyl tocopherol succinate (ATS) was designed, synthesized and characterized via FT-IR, HR-MS, H1 NMR and C13 NMR, to simultaneously confer biomimetic and dual responsive properties of an antibiotic nanosystem to enhance their antibacterial efficacy and reduce antimicrobial resistance. Therefore, an in silico-aided design (to mimic the natural substrate of bacterial lipase) was employed to demonstrate the binding potential of ATS to lipase (−32.93 kcal/mol bi...
Source
#1Cláudia Costa (University of Porto)H-Index: 4
#2Sara C. Cunha (University of Porto)H-Index: 44
Last. Ana Silva (University of Porto)H-Index: 57
view all 10 authors...
Abstract null null Diazepam is commonly used in the management of epileptic seizures, although it has limitations that can be overcome by using formulations that are easier to administer and capable of directing the drug to the brain. In this field, it has been reported that the use of nanostructured lipid carriers (NLC) via intranasal (or via nose-to-brain) promotes the targeting of drugs to the brain, improving the effectiveness of therapy. null The aim of this work was to optimize two diazepa...
Source
#1Salma E. El-Habashy (Alexandria University)H-Index: 3
#2Amal H. El-Kamel (Alexandria University)H-Index: 19
Last. Hoda M. Eltaher (Alexandria University)H-Index: 3
view all 5 authors...
Abstract null null 3D printing has revolutionized pharmaceutical research, with applications encompassing tissue regeneration and drug delivery. Adopting 3D printing for pharmaceutical drug delivery personalization via nanoparticle-reinforced hydrogel scaffolds promises great regenerative potential. Herein, we engineered novel core/shell, bio-inspired, drug-loaded polymeric hydrogel scaffolds for pharmaceutically personalized drug delivery and superior osteoregeneration. Scaffolds were developed...
Source
#1Qichun Song (Xi'an Jiaotong University)
#2Selvakani Prabakaran (MKU: Madurai Kamaraj University)H-Index: 3
Last. Mariappan Rajan (MKU: Madurai Kamaraj University)H-Index: 21
view all 7 authors...
Abstract null null One of the very reliable, attractive, and cheapest techniques for synthesizing nanofibers for biomedical applications is electrospinning. Here, we have created a novel nanofibrous composite coated Ti plate to mimic an Extra Cellular Matrix (ECM) in order to enhance the bone tissue regeneration. An electrospun fibrous composite was obtained by the combination of minerals (Zn, Mg, Si) substituted hydroxyapatite (MHAP)/Polyethylene Glycol (PEG)/Cissus quadrangularis (CQ) extract....
Source
#1Cedrine de Backere (UGent: Ghent University)H-Index: 2
#2Thomas De Beer (UGent: Ghent University)H-Index: 34
Last. Valérie Vanhoorne (UGent: Ghent University)H-Index: 22
view all 4 authors...
Abstract null null The effect of different binders for direct compression on tablet critical quality attributes was investigated. Dicalcium phosphate, lactose and microcrystalline cellulose were used as fillers and combined with ten binders (10, 20 and 30% w/w). Binder properties were linked to tensile strength via partial least square analysis. Tablets containing VA64F and PH105 exhibited the highest tensile strength which was linked to their compaction properties (specific work of compaction, ...
Source
#1Mona M. AgwaH-Index: 5
#2Marwa M. Abu-SerieH-Index: 1
Last. Sally Sabra (Alexandria University)H-Index: 9
view all 7 authors...
Abstract null null Targeted delivery of cytotoxic drugs has shown great potential in cancer therapy. In this light, vitamin D3 (vit.D3)-coated micelles were fabricated to encapsulate the cytotoxic drug; etoposide (ETP). Sodium caseinate micelles were first utilized to encapsulate vit.D3 and ETP within their hydrophobic core, then drug-loaded micelles were further decorated with an envelope of vit.D3/ phospholipid complex to enhance the active targeting potency of fabricated micelles via exploiti...
Source
#1Li Ge Wang (University of Sheffield)H-Index: 5
#2John P. Morrissey (Edin.: University of Edinburgh)H-Index: 3
Last. James D. Litster (University of Sheffield)H-Index: 47
view all 8 authors...
Abstract null null This paper presents a generic framework of Model Driven Design (MDD) with its application for a twin screw granulation process using a mechanistic-based population balance model (PBM). The process kernels including nucleation, breakage, layering and consolidation are defined in the PBM. A recently developed breakage kernel is used with key physics incorporated in the model formulation. Prior to granulation experiments, sensitivity analysis of PBM parameters is performed to inv...
Source
#1Wenwen Xu (SPU: Shenyang Pharmaceutical University)
#2Chao Liu (SPU: Shenyang Pharmaceutical University)H-Index: 13
Last. Liang Fang (SPU: Shenyang Pharmaceutical University)H-Index: 24
view all 6 authors...
Abstract null null The aim of present work was to investigate the influence of drug physicochemical properties on the enhancement effect of enhancers, which guided the application of enhancers in different drug transdermal prescriptions. Firstly, Polyglyceryl-3 dioleate (POCC) was selected as a model enhancer and its enhancement effect on ten drugs was assessed by in vitro skin permeation experiment. Secondly, the correlation analysis of physicochemical properties of drugs was carried out from t...
Source
12345678910
Top fields of study
Organic chemistry
Chemistry
Materials science
Drug delivery
Chromatography
Dosage form
Pharmacology