International Journal of Pharmaceutics
Papers 10,000
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#1Carolina Corzo (Graz University of Technology)H-Index: 1
#2Agnes Fuchsbichler (Graz University of Technology)
Last. Sharareh Salar-Behzadi (Graz University of Technology)H-Index: 10
view all 8 authors...
Abstract null null Spray-drying is an extensively used technology for engineering inhalable particles. Important technical hurdles are however experienced when lipid-based excipients (LBEs) are spray-dried. Stickiness, extensive wall deposition, or simply inability to yield a solid product have been associated to the low melting points of LBEs. In this work, solutions containing polyglycerol esters of behenic acid (PGFA-behenates), or other high melting point LBEs, were spray-dried to produce ib...
#1Kalvatala Sudhakar (Lovely Professional University)H-Index: 5
#2Vijay Mishra (Lovely Professional University)H-Index: 21
Last. Murtaza M. Tambuwala (UU: University of Ulster)H-Index: 24
view all 6 authors...
Abstract null null The skin embodies a relatively large and readily accessible surface area to absorb a drug through a non-invasive procedure. The vesicular carrier systems such as liposomes, ethosomes, and transethosomes have been explored as non-invasive systems for transdermal delivery of drugs. In the present study, different vesicular carriers were prepared by the thin-film hydration method with modification, and various parameters like size, elasticity, and release profiles were evaluated....
#1Mohammad Kashif Iqubal (Jamia Hamdard)H-Index: 7
#2Ashif Iqubal (Jamia Hamdard)H-Index: 9
Last. Sanjula Baboota (Jamia Hamdard)H-Index: 54
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Abstract null null The current study has been designed to appraise the efficacy of developed combinatorial lipid-nanosystem-based gel (linogel) of 5-fluorouracil and resveratrol for skin cancer treatment. Initially, linogel was prepared and characterized for different parameters, namely pH, texture, drug content uniformity, occlusiveness, etc. Then in vivo efficacy studies (tumor number, area, and volume, histopathology, ultrastructural and immunohistochemical analysis) of linogel were determine...
#1Chikako Morikawa (Chiba University)H-Index: 1
#2Keisuke Ueda (Chiba University)H-Index: 17
Last. Kunikazu Moribe (Chiba University)H-Index: 30
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Abstract null null The present study focuses on the effect of the preparation temperature on the physicochemical properties of amorphous drug nanoparticles to clarify their formation mechanism. Amorphous glibenclamide (GLB) nanoparticles were prepared at 4–40 °C using two antisolvent precipitation methods. In method A, N,N-dimethylformamide (DMF) solution of GLB was added to an aqueous solution containing hydroxypropyl methylcellulose (HPMC) to obtain nano-A suspensions. In method B, nano-B susp...
#1Satish KumarH-Index: 35
Last. Shery Jacob (GMU: Gulf Medical University)H-Index: 17
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Abstract null null The cassette dosing technique is employed in the drug discovery stage of non-clinical studies to obtain pharmacokinetic data from multiple drug candidates in a single experiment. The objective of the current investigation was to evaluate the effect of sex and food on the selected pharmacokinetic parameters of four biopharmaceutical classification system (BCS) drugs (BCS-I: propranolol, BCS-II: diclofenac, BCS-III: atenolol, and BCS-IV: acetazolamide) utilizing cassette dosing ...
#1Pooja Bhalode (RU: Rutgers, The State University of New Jersey)H-Index: 4
#2Huayu Tian (UD: University of Delaware)
Last. Marianthi G. Ierapetritou (UD: University of Delaware)H-Index: 65
view all 10 authors...
Abstract null null While continuous manufacturing (CM) of pharmaceutical solid-based drug products has been shown to be advantageous for improving the product quality and process efficiency in alignment with FDA’s support of the quality-by-design paradigm (Lee, 2015; Ierapetritou et al., 2016; Plumb, 2005; Schaber, 2011), it is critical to enable full utilization of CM technology for robust production and commercialization (Schaber, 2011; null Byrn, 2015 ). To do so, an important prerequisite is...
#1Yugo A Martins (USP: Universidade de São Paulo)H-Index: 1
#2Theo Z. Pavan (USP: Universidade de São Paulo)H-Index: 15
Last. Renata Fonseca Vianna Lopez (USP: Universidade de São Paulo)H-Index: 29
view all 3 authors...
Abstract null null Sonodynamic therapy (SDT) is a new therapeutic modality for noninvasive cancer treatment based on the association of ultrasound and sonosensitizer drugs. Up to date, there is not a consensus on the standardization of the experimental conditions for the in vitro studies to correctly assess cell viability during SDT. Therefore, this review article mainly describes how the main ultrasound parameters and experimental setups of ultrasound application in vitro studies can influence ...
#1Tom Bourguignon (University of Paris-Saclay)H-Index: 1
#2Adriano A. Torrano (LMU: Ludwig-Maximilians-Universität München)H-Index: 10
Last. Ruxandra Gref (University of Paris-Saclay)H-Index: 65
view all 6 authors...
Abstract null null Poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) are among the most employed (co)polymers for the preparation of drug nanocarriers for the treatment of cancer and infectious diseases. Before considering any clinical use, it is necessary to understand the interactions between polymeric nanoparticles (NPs) and their physiological environment, especially immune cells. Here, we propose a simple, yet precise method to assess NPs internalization kinetics in macrophag...
#1Mostafa Sulaiman (Princeton University)H-Index: 1
#2Xiaoyu Liu (Princeton University)H-Index: 3
Last. Sankaran Sundaresan (Princeton University)H-Index: 64
view all 3 authors...
Abstract null null The transport and aerosolization of particles are studied in several different dry powder inhaler geometries via Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) simulations. These simulations combine Large Eddy Simulation of gas with Discrete Element Model simulation of all the carrier particles and a representative subset of the active pharmaceutical ingredient (API) particles. The purpose of the study is to probe the dominant mechanism leading to the release o...
#1Yeakuty Jhanker (Curtin University)
#2Melinda N. Mbano (Curtin University)
Last. Heather A. E. Benson (Curtin University)H-Index: 37
view all 7 authors...
Abstract null null Physical drug delivery enhancement in skin has been shown to enhance cosmeceutical actives efficacy. Among the physical drug delivery enhancement technologies, microneedle is the most commercially successful technology. However, there are pros and cons like other physical enhancement technologies including variabilities in penetration depth and lack of efficacy. In this study, three physical topical dug delivery enhancements, elongated microparticles, microneedles and dermarol...
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