Abstract PO-011: Targeting colorectal cancer stem/progenitor cells with a combination of ionizing radiation and thymoquinone

Introduction: Radiotherapy is a standard neo-adjuvant therapy for cancer treatment, the success of which is limited by the resistance of cancer stem cells (CSCs) to therapy in addition to the deleterious effects of ionizing radiation (IR) to surrounding normal tissues. Despite the anticancer efficacy of combining IR with standard chemotherapeutic drugs, such treatments have shown great toxicity to normal cells. Thus, recent therapeutic...