Original paper
ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
Abstract
Cyclic dinucleotide (CDN) agonists of the STimulator of InterferoN Genes (STING) pathway have shown immune activation and tumor clearance in pre-clinical models. However, CDNs administered intratumorally also promote STING activation leading to direct cytotoxicity of many cell types in the tumor microenvironment (TME), systemic inflammation due to rapid tumor extravasation of the CDN, and immune ablation in the TME. These result in a failure to...
Paper Details
Title
ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
Published Date
Apr 22, 2021
Journal
Volume
4
Issue
1