Pathology

Cell

Omics

Disease

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Bioinformatics

Biology

Outbreak

Virology

Immunology

2019-20 coronavirus outbreak

Computational biology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Genetics

Medicine

Immune system

Nature Medicine

Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19. We identified expansion of nonclassical monocytes expressing complement transcripts (CD16

Single-cell multi-omics analysis of the immune response in COVID-19