Original paper

Mitochondrial NADP(H) generation is essential for proline biosynthesis

Science56.90
Volume: 372, Issue: 6545, Pages: 968 - 972
Published: May 28, 2021
Abstract
Providing for protein synthesis Compartmentalization of metabolic processes into organelles can have important consequences. Zhu et al. examined the role of the coenzyme nicotinamide adenine dinucleotide phosphate (NADP + ) and its reduced form (NADPH) in cultured human cells. They found that cells lacking NAD kinase 2, an enzyme needed to make NADPH, had decreased abundance of mitochondrial NADPH and proliferated slowly in culture medium with...
Paper Details
Title
Mitochondrial NADP(H) generation is essential for proline biosynthesis
Published Date
May 28, 2021
Journal
Volume
372
Issue
6545
Pages
968 - 972
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