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Original paper

Mitochondrial NADP(H) generation is essential for proline biosynthesis

Science44.70
Volume: 372, Issue: 6545, Pages: 968 - 972
Published: Apr 22, 2021
Abstract
The coenzyme nicotinamide adenine dinucleotide phosphate (NADP+) and its reduced form (NADPH) regulate reductive metabolism in a subcellularly compartmentalized manner. Mitochondrial NADP(H) production depends on the phosphorylation of NAD(H) by NAD kinase 2 (NADK2). Deletion of NADK2 in human cell lines did not alter mitochondrial folate pathway activity, tricarboxylic acid cycle activity, or mitochondrial oxidative stress, but rather led to...
Paper Details
Title
Mitochondrial NADP(H) generation is essential for proline biosynthesis
Published Date
Apr 22, 2021
Journal
Volume
372
Issue
6545
Pages
968 - 972
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