Review paper
mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
Abstract
A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they have to be stored at (ultra)low temperatures. Understanding the root cause of the instability of these vaccines may help to rationally improve mRNA-LNP product stability and thereby ease the temperature conditions for storage. In this review we discuss proposed structures of mRNA-LNPs, factors that impact mRNA-LNP stability and strategies to optimize mRNA-LNP...
Paper Details
Title
mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
Published Date
May 1, 2021
Volume
601
Pages
120586 - 120586
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