The endocannabinoid 2-arachidonoylglycerol inhibits endothelial function and repair through cannabinoid 1 (CB1) receptor.

Published on Apr 1, 2021in International Journal of Cardiology3.229
· DOI :10.1016/J.IJCARD.2020.11.027
Lian-Jie Hou3
Estimated H-index: 3
(Guangzhou Medical University),
Mei-Ying Xie2
Estimated H-index: 2
+ 1 AuthorsGuo-Jun Zhao5
Estimated H-index: 5
(Guangzhou Medical University)
Sources
Abstract
📖 Papers frequently viewed together
1 Citations
References5
Newest
#1J Jehle (University Hospital Bonn)H-Index: 3
#2L Eich (University Hospital Bonn)H-Index: 1
Last. Georg Nickenig (University Hospital Bonn)H-Index: 53
view all 10 authors...
Abstract Background Endothelial dysfunction promotes atherogenesis, vascular inflammation, and thrombus formation. Reendothelialization after angioplasty is required in order to prevent stent failure. Previous studies have highlighted the role of 2-arachidonoylglycerol (2-AG) in murine experimental atherogenesis and in human coronary artery disease. However, the impact of 2-AG on endothelial repair and leukocyte–endothelial cell adhesion is still unknown. Methods Endothelial repair was studied i...
4 CitationsSource
#1Olga Karpińska (UMB: Medical University of Białystok)H-Index: 4
#2Marta Baranowska-Kuczko (UMB: Medical University of Białystok)H-Index: 8
Last. Hanna Kozłowska (UMB: Medical University of Białystok)H-Index: 12
view all 8 authors...
Recent evidence suggests that endocannabinoids acting via cannabinoid CB1 receptors may modulate vascular responses of various vasoconstrictors in the rodent systemic vasculature. The aim of the study was to investigate whether endocannabinoids modulate the contractile responses evoked by a thromboxane A2 analog (U46619), angiotensin II (ANG II), serotonin (5-HT), and phenylephrine, which stimulate distinct Gq/11 protein-coupled receptors (thromboxane, ANG II type 1, 5-HT2, and α1-adrenergic rec...
11 CitationsSource
#1Valeria Gasperi (Sapienza University of Rome)H-Index: 28
#2D Evangelista (Sapienza University of Rome)H-Index: 6
Last. Mauro Maccarrone (Sapienza University of Rome)H-Index: 90
view all 9 authors...
Abstract Accumulated evidence points to a key role for endocannabinoids in cell migration, and here we sought to characterize the role of these substances in early events that modulate communication between endothelial cells and leukocytes. We found that 2-arachidonoylglycerol (2-AG) was able to initiate and complete the leukocyte adhesion cascade, by modulating the expression of selectins. A short exposure of primary human umbilical vein endothelial cells (HUVECs) to 2-AG was sufficient to prim...
29 CitationsSource
#1Shimin Li (IU: Indiana University Bloomington)H-Index: 8
#2Sherry Hu (IU: Indiana University Bloomington)H-Index: 1
Last. Joseph A. Bonanno (IU: Indiana University Bloomington)H-Index: 31
view all 5 authors...
1 Citations
#1Mohanraj Rajesh (NIH: National Institutes of Health)H-Index: 37
#2Partha Mukhopadhyay (NIH: National Institutes of Health)H-Index: 62
Last. Pal Pacher (NIH: National Institutes of Health)H-Index: 117
view all 6 authors...
Background and purpose: Impaired endothelial activity and/or cell death play a critical role in the development of vascular dysfunction associated with congestive heart failure, diabetic complications, hypertension, coronary artery disease and atherosclerosis. Increasing evidence suggests that cannabinoid 1 (CB1) receptor inhibition is beneficial in atherosclerosis and cardiovascular inflammation both in experimental models, as well as in humans. Here, we investigated the effects of CB1 receptor...
119 CitationsSource
Cited By1
Newest
Source