Successful deceased donor kidney transplantation to a recipient with a history of COVID-19 treatment.

Published on Mar 29, 2021in Journal of Infection and Chemotherapy1.722
· DOI :10.1016/J.JIAC.2021.03.018
Kasumi Yoshinaga3
Estimated H-index: 3
(Okayama University),
Motoo Araki17
Estimated H-index: 17
+ 22 AuthorsH. Nakajima
Sources
Abstract
Abstract Case presentation. A 49-year-old Asian male, who had undergone hemodialysis for >16 years, complained of a fever, dysgeusia and dysosmia, and was diagnosed with COVID-19 pneumonia based on severe acute respiratory syndrome coronavirus 2 polymerase chain reaction (SARS-CoV-2 PCR) and computed tomography (CT). Treatment was started with oral favipiravir and ciclesonide inhalation. On the 10th day of treatment, the patient had a persistent high fever and a chest CT showed exacerbation of pneumonia, so dexamethasone was intravenously started. He was discharged after confirming two consecutive negative SARS-CoV-2 PCR tests. Three months after COVID-19 treatment, a SARS-CoV-2 PCR test was negative and he underwent a deceased donor kidney transplantation. Basiliximab induction with triple drug immunosuppression consisting of extended-release tacrolimus, mycophenolate mofetil and prednisolone, which is our regular immunosuppression protocol, was used. He was discharged on postoperative day 18 without the need for postoperative hemodialysis or any complications. The serum creatinine level was 1.72 mg/dL 95 days postoperatively and he had a favorable clinical course that was similar to deceased donor kidney recipients without a history of SARS-CoV-2 infection. Conclusion. We report the first case of a kidney transplantation after COVID-19 treatment in Japan and the fourth case globally. We would like to provide information about our successful case due to the anticipated increase in similar candidates in the near future.
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References9
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#1Prabhu KanchiH-Index: 1
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#1Giovanni VarottiH-Index: 16
#2Ferdinando DodiH-Index: 11
Last. Iris FontanaH-Index: 18
view all 4 authors...
COVID-19, the ongoing pandemic caused by SARS-CoV-2, has had a dramatic impact on transplant systems in the most affected countries, namely Italy. Preliminary data indicates that patients on hemodialysis therapy as well kidney transplant (KTx) recipients appear to be particularly susceptible to COVID-19 illness due to immunosuppression and coexisting conditions. Currently, there is a lack of data concerning the biologic behavior, recurrence and long-term morbidity of COVID-19 and there are no ex...
2 CitationsSource
#1Kan KikuchiH-Index: 10
#2Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 81
Last. Tadao Akizawa (Memorial Hospital of South Bend)H-Index: 1
view all 11 authors...
In Japan, the first case of COVID-19 in dialysis patients was reported on March 1, 2020. A total of 31 cases were reported by April 10, and it increased to 95 by May 15. Thereafter, with the rapid increase in the number of COVID-19 cases in the general population since late March, there was a not surprising increase in the number of COVID-19 cases in dialysis patients. The mortality rate is 16.2% (16/99 cases) in dialysis patients, which is higher than 5.3% (874/16532 cases) in the general popul...
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#1Claudia Benedetti (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 3
#2Meryl Waldman (NIH: National Institutes of Health)H-Index: 14
Last. Paolo Cravedi (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 34
view all 5 authors...
Novel coronavirus disease 2019 (COVID-19) has become a worldwide emergency health problem. The disease occurs mostly in individuals between 30-79 years of age and 81% of cases are mild. However, it may result in progressive respiratory failure owing to alveolar damage and can be fatal in 3.6% of the cases. Direct viral injury, uncontrolled inflammation, and activation of coagulation and complement cascades are thought to participate in disease pathogenesis. Patients with COVID-19 often display k...
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#1Paolo Cravedi (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 34
#2Suraj Sarvode Mothi (Brigham and Women's Hospital)H-Index: 9
Last. Leonardo V. Riella (Harvard University)H-Index: 27
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Kidney transplant recipients may be at high risk of developing critical COVID-19 illness due to chronic immunosuppression and comorbidities. We identified hospitalized adult kidney transplant recipients at 12 transplant centers in the US, Italy and Spain who tested positive for COVID-19. Clinical presentation, laboratory values, immunosuppression and treatment strategies were reviewed and predictors of poor clinical outcomes were determined through multivariable analyses. Among 9,845 kidney tran...
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#1Federico Alberici (University of Brescia)H-Index: 21
#2Elisa DelbarbaH-Index: 5
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Abstract The outcome of SARS-CoV2 infection in patients who have received a kidney allograft and are being treated with immunosuppression is unclear. We describe 20 kidney transplant recipients (median age 59 years [inter quartile range 51-64 years], median age of transplant 13 years [9-20 years], baseline eGFR 36.5 [23-47.5]) with SARS-CoV2 induced pneumonia. At admission, all had immunosuppression withdrawn and were started on methylprednisolone 16 mg/day, all but one was commenced on antivira...
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#2Eric H. Y. Lau (HKU: University of Hong Kong)H-Index: 38
Last. Gabriel M. Leung (HKU: University of Hong Kong)H-Index: 97
view all 23 authors...
We report temporal patterns of viral shedding in 94 patients with laboratory-confirmed COVID-19 and modeled COVID-19 infectiousness profiles from a separate sample of 77 infector–infectee transmission pairs. We observed the highest viral load in throat swabs at the time of symptom onset, and inferred that infectiousness peaked on or before symptom onset. We estimated that 44% (95% confidence interval, 25–69%) of secondary cases were infected during the index cases’ presymptomatic stage, in setti...
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#1Brandon Michael Henry (Cincinnati Children's Hospital Medical Center)H-Index: 33
#2Giuseppe Lippi (University of Verona)H-Index: 107
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