Journal of Infection and Chemotherapy
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Abstract Rapid antigen tests (RATs) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have advantages over viral culture in terms of cost and rapidity of testing, but they have low sensitivity. In addition, RATs tend to be negative from approximately 11 days after symptom onset. To determine whether the antigen-negative state indicates a lack of infectiousness, we assessed the association between viral culture and RAT results. Viral culture, reverse transcription-quantitative poly...
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#1Hai-Ying Yu (ZJU: Zhejiang University)
#2Tingting Qu (ZJU: Zhejiang University)H-Index: 12
Last. Jifang Sheng (ZJU: Zhejiang University)H-Index: 30
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Abstract null null Background null Central nervous system (CNS) infection due to Exophiala dermatitidis is rare and fatal, and primarily reported in immunocompromised patients or those with caspase recruitment domain-containing protein 9 deficiency. Herein, we describe a case of an otherwise healthy person (without underlying disease or gene deficiency) diagnosed with Exophiala dermatitidis meningoencephalitis. The patient achieved clinical remission under high-dose antifungal therapy in the fir...
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#1Ryo Kobayashi (Sapporo Medical University)H-Index: 2
#2Ryosei Murai (Sapporo Medical University)H-Index: 3
Last. Yuki Katayama (Sapporo Medical University)
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Abstract null null Introduction null Highly sensitive reagents for detecting SARS-CoV-2 antigens have been developed for accurate and rapid diagnosis till date. In this study, we aim to clarify the frequency of false-positive reactions and reveal their details in SARS-CoV-2 quantitative antigen test using an automated laboratory device. null null null Methods null Nasopharyngeal swab samples (n = 4992) and saliva samples (n = 5430) were collected. We measured their SARS-CoV-2 antigen using Lumip...
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#1Masamitsu Kono (Wakayama Medical University)H-Index: 10
#2Gen Sugita (Wakayama Medical University)H-Index: 4
Last. Muneki Hotomi (Wakayama Medical University)H-Index: 23
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OBJECTIVES We investigated changes in prescriptions for antimicrobial agents to treat children with acute otitis media (AOM). METHODS A descriptive study using an electronic medical record database. Of 199,896 patients enrolled between 2001 and 2019, a total of 10,797 were aged <16 years and had AOM as their first and primary disease (overall pediatric AOM cohort). In addition, 4786 patients with AOM without other comorbidities (pediatric AOM cohort) were included. RESULTS In the overall pediatr...
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#1Shogo Otake (Boston Children's Hospital)
Last. Masashi Kasai (Boston Children's Hospital)H-Index: 6
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Cronobacter spp. cause serious diseases, such as necrotizing enterocolitis, bacteremia, and meningitis in neonates and infants. Most Cronobacter-associated meningitis is reportedly due to C. sakazakii and the majority of infections caused by C. malonaticus occur in adults and are less severe. We report the case of meningitis and brain abscess caused by C. malonaticus Sequence Type (ST) 440 in a healthy full-term neonate. We should consider the possibility that full-term neonates may develop meni...
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#1Hitoshi Yonezawa (Sapporo Medical University)H-Index: 1
#2Shingo Tanaka (Sapporo Medical University)H-Index: 9
Last. Junji Kato (Sapporo Medical University)H-Index: 40
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Abstract null null Introduction null In quantitative assays for hepatitis B virus (HBV) DNA, although the amplification reaction signal is detected for low-positive cases, quantification remains challenging. HBV reactivation has been reported in many studies, but only a few have focused on HBV low-positive cases. This study aimed to determine the reactivation rate and risk factors for HBV reactivation in low-positive cases. null null null Methods null In this retrospective cohort study, we analy...
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#1Satoshi Ide (Tohoku University)H-Index: 7
#2Satoshi KutsunaH-Index: 16
Last. Norio OhmagariH-Index: 24
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Histoplasmosis is a fungal infection caused by Histoplasma capsulatum, and Japan is considered a non-endemic area for histoplasmosis. Most patients diagnosed with histoplasmosis in the past usually have exposure to caves and bat guano with travel history to endemic areas. Therefore, travel history and risk activities should be comprehensively assessed when suspecting histoplasmosis because this important information may be overlooked. Although few, possibilities of indigenous cases have also bee...
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#1Zhenyan Wang (Fudan University)H-Index: 11
#2Renfang Zhang (Fudan University)H-Index: 14
Last. Yixiao Lin (Fudan University)H-Index: 1
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Introduction Lymphoma is the most common cancer in HIV/AIDS patients. Chemotherapy regiments recommended for lymphomas in HIV-negative patients are also used for lymphomas in HIV/AIDS patients. Little is known about the infections among HIV/AIDS patients with lymphoma undergoing chemotherapy. Methods This retrospective study investigated the incidence, spectrum of and risk factors for infections during chemotherapy in 164 HIV/AIDS patients with lymphoma admitted to Shanghai Public Health Clinica...
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#1Nobuhiro Asai (Aichi Medical University)H-Index: 14
#2Hiroyuki Suematsu (Aichi Medical University)H-Index: 11
Last. Yusuke Koizumi (Aichi Medical University)H-Index: 12
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Abstract null null Introduction null Aspiration pneumonia (AP) accounts for 5.0–53.2% of hospitalized pneumonia and the treatment commonly used is by broad-spectrum antibiotics to cover anaerobes. Since ceftriaxone (CTRX) could generally cover oral streptococcus and anaerobes implicated in AP, it could be a useful option in the treatment of AP, instead of piperacillin-tazobactam/(PIPC/TAZ) or Carbapenems. null null null Patients and methods null For the purpose of examining whether CTRX is as ef...
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#1Yujin Nozaki (Saitama Medical University)
#2Daisuke Ono (Saitama Medical University)
Last. Hideaki Oka (Saitama Medical University)H-Index: 2
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Abstract null null Melioidosis, an infectious disease caused by Burkholderia pseudomallei, is endemic in specific regions, including Southeast Asia and Northern Australia. In Japan, where no autochthonous has been reported to date, melioidosis is a rare infectious disease. Herein, we report a case of melioidosis in a 68-year-old Japanese man with renal abscess and bacteremia, but without pneumonia. The patient presented to our hospital and was admitted for fever and chills that have persisted fo...
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