Factors associated with prior acute pancreatitis episodes among patients with chronic pancreatitis

Published on Mar 20, 2021in Digestive and Liver Disease3.57
· DOI :10.1016/J.DLD.2021.03.001
Nan Ru3
Estimated H-index: 3
,
Jia-Hui Zhu4
Estimated H-index: 4
+ 10 AuthorsZhuan Liao19
Estimated H-index: 19
Sources
Abstract
Abstract Background The relationship between chronic pancreatitis (CP) and acute pancreatitis (AP) is complex and not well understood. CP could be preceded by antecedent episodes of AP. Aims The aim of this study was to explore both genetic and environmental factors associated with AP episodes before the diagnosis of CP. Methods This was a cross-sectional study including 1022 patients. Detailed demographic, genetic, and clinical data were collected. Based on the presence of AP episode(s) before diagnosis of CP, patients were divided into AP group (further classified into single episode of AP group and recurrent AP group) and non-AP group. Related factors among these groups were assessed using multivariate logistic regression model. Results Before diagnosis of CP, 737 patients (72.1%) had a history of AP. Smoking(P = 0.005) and heavy alcohol consumption(P = 0.002) were risk factors for AP while age at CP onset(P  Conclusions SPINK1 mutations served as protective factor for AP episodes, suggesting SPINK1 mutation might play a pathogenic role in CP occurrence with occult clinical manifestations.
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3 CitationsSource
#1Nan Ru ('SMMU': Second Military Medical University)H-Index: 3
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1 CitationsSource
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4 CitationsSource
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Importance Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas with a prevalence of 42 to 73 per 100 000 adults in the United States. Observations Both genetic and environmental factors are thought to contribute to the pathogenesis of CP. Environmental factors associated with CP include alcohol abuse (odds ratio [OR], 3.1; 95% CI, 1.87-5.14) for 5 or more drinks per day vs abstainers and light drinkers as well as smoking (OR, 4.59; 95% CI, 2.91-7.25) for more...
59 CitationsSource
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Abstract Background The sentinel acute pancreatitis event (SAPE) hypothesis for pathogenesis of chronic pancreatitis (CP) postulates that acute pancreatitis (AP), especially recurrent AP (RAP), precedes development of CP. However, in a recent population-based study, 52/89 (58.4%) of CP had no prior episodes of AP. In a large clinic-based CP cohort we aimed to determine the incidence and timing of prior AP in patients diagnosed with CP. Methods We retrospectively identified 499 consecutive patien...
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