Naloxone-induced analgesia mediated by central kappa opioid system in chronic inflammatory pain
Abstract
Opioids, which are widely used for the treatment of chronic pain, have an analgesic effect by mainly activating mu-opioid receptor (MOR). Paradoxically, a high dose of naloxone, non-selective opioid receptor antagonist, is also known to induce analgesia, but the underlying mechanism remains unclear. Since kappa-opioid receptor (KOR) and dynorphin (KOR ligand) have been implicated in the naloxone-induced analgesia, we aimed to elucidate its...
Paper Details
Title
Naloxone-induced analgesia mediated by central kappa opioid system in chronic inflammatory pain
Published Date
Jul 1, 2021
Journal
Volume
1762
Pages
147445 - 147445
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