Brain Research
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#1Amie Durston (UW: University of Waterloo)H-Index: 1
#2Roxane J. Itier (UW: University of Waterloo)H-Index: 28
Abstract Most ERP studies on facial expressions of emotion have yielded inconsistent results regarding the time course of emotion effects and their possible modulation by task demands. Most studies have used classical statistical methods with a high likelihood of type I and type II errors, which can be limited with Mass Univariate statistics. FMUT and LIMO are currently the only two available toolboxes for Mass Univariate analysis of ERP data and use different fundamental statistics. Yet, no dir...
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#1Takashi Kubota (Tokushima Bunri University)H-Index: 3
#2Yutaka Kirino (Tokushima Bunri University)H-Index: 50
Abstract Insoluble, fibrillar intraneuronal accumulation of the tau protein termed neurofibrillary tangles (NFTs), are characteristic hallmarks of Alzheimer’s disease (AD). They play a significant role in the behavioral phenotypes of AD. Certain mice (rTg4510) constitutively express mutant human tau until transgene expression is inactivated by the administration of doxycycline (DOX). The present study aimed to determine the timing of the onset of memory impairment in rTg4510 mice and define the ...
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#1Huifang Cao (Hebei Medical University)
#2Lichao Zhang (Hebei Medical University)
Last. Weiping Wang (Hebei Medical University)H-Index: 13
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Status epilepticus (SE) is a neurological emergency. The pathological hallmark of neuronal damage after epileptic seizures could be the chain reaction of oxygen free radicals. Hydroxylated fullerenes (HFs) are novel and effective free radical scavengers, which play an important role in various neurological diseases. However, whether they have a protective effect against epileptic seizures remains elusive. Our study explores the effect of pretreatment with HFs in different doses (0.5, 5, and 10 m...
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#1Ryan J. Hubbard (UIUC: University of Illinois at Urbana–Champaign)H-Index: 3
#2Kara D. Federmeier (UIUC: University of Illinois at Urbana–Champaign)H-Index: 55
Although we often seem to successfully comprehend language in the face of distraction, few studies have examined the role of sustained attention in critical components of sentence processing, such as integrating information over a sentence and revising predictions when unexpected information is encountered. The current study investigated the impact of attention on sentence processing using a novel dual-task paradigm. Participants read weakly and strongly constraining sentences with expected or u...
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#1Pearl A. Sutter (UConn: University of Connecticut)H-Index: 2
#2Megan Rouillard (UConn: University of Connecticut)H-Index: 1
Last. Stephen J. Crocker (UConn: University of Connecticut)H-Index: 29
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Abstract Astrocytic injury responses are known to be influenced by the extracellular matrix (ECM). Astrocytes are also recognized as a source of extracellular vesicles (EVs) that can impact the activity and function of other astrocytes and cell types. Whether the ECM influences the function of astrocytic EVs in the context of wound recovery has not been previously studied. We report EVs from astrocytes cultured on varied ECM substrates are sufficient to elicit distinct injury responses in naive ...
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#1Kiera T. Blawn (UA: University of Arizona)H-Index: 1
#2Kathryn L. Kellohen (UA: University of Arizona)H-Index: 2
Last. Tally M. Largent-Milnes (UA: University of Arizona)H-Index: 21
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BACKGROUND Sex hormones have been implicated in pH regulation of numerous physiological systems. One consistent factor of these studies is the sodium-hydrogen exchanger 1 (NHE1). NHE1 has been associated with pH homeostasis at epithelial barriers. Hormone fluctuations have been implicated in protection and risk for breaches in blood brain barrier (BBB)/blood endothelial barrier (BEB) integrity. Few studies, however, have investigated BBB/BEB integrity in neurological disorders in the context of ...
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#1Mauricio Sepulveda (University of Melbourne)
#2Elizabeth E. Manning (University of Melbourne)H-Index: 8
Last. Maarten van den Buuse (JCU: James Cook University)H-Index: 47
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Abstract To assess the long-term effects of chronic adolescent methamphetamine (METH) treatment on the serotonin system in the brain, we used serotonin-1A receptor (5-HT1A) and serotonin transporter (SERT) autoradiography, and quantitative tryptophan-hydroxylase 2 (TPH2) immunohistochemistry in the raphe nuclei of mice. Because of the modulatory role of brain-derived neurotrophic factor (BDNF) on the serotonin system and the effects of METH, we included both BDNF heterozygous (HET) mice and wild...
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#1Grace J. Lee (UPR-RP: UPRRP College of Natural Sciences)H-Index: 1
#2Shin Ae Kim (SNU: Seoul National University)
Last. Seog Bae Oh (UPR-RP: UPRRP College of Natural Sciences)H-Index: 37
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Opioids, which are widely used for the treatment of chronic pain, have an analgesic effect by mainly activating mu-opioid receptor (MOR). Paradoxically, a high dose of naloxone, non-selective opioid receptor antagonist, is also known to induce analgesia, but the underlying mechanism remains unclear. Since kappa-opioid receptor (KOR) and dynorphin (KOR ligand) have been implicated in the naloxone-induced analgesia, we aimed to elucidate its mechanism by focusing on the kappa-opioid system in the ...
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#1Omar Fernando Robayo Avendaño (Pedagogical and Technological University of Colombia)
#2Ximena Alvira Botero (UAM: Autonomous University of Madrid)
Last. Miguel Garzón (UAM: Autonomous University of Madrid)H-Index: 20
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Abstract The Locus Coeruleus (LC) is a pontine nucleus involved in many physiological processes, including the control of the sleep/wake cycle (SWC). At cellular level, the LC displays a high density of opioid receptors whose activation decreases the activity of LC noradrenergic neurons. Also, microinjections of morphine administered locally in the LC of the cat produce sleep associated with synchronized brain activity in the electroencephalogram (EEG). Even though much of the research on sleep ...
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#1Mathew R. Hammerstrom (UVic: University of Victoria)H-Index: 1
#2Thomas D. Ferguson (UVic: University of Victoria)H-Index: 3
Last. Olave E. Krigolson (UVic: University of Victoria)H-Index: 21
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Abstract Humans often rely on feedback to learn. Indeed, in learning the difference between feedback and an expected outcome is computed to inform future actions. Further, recent work has found that reward and feedback have a unique role in modulating conflict processing and cognitive control. However, it is still not clear how conflict, especially concerning the processing and evaluation of feedback, impacts learning. To address this, we examined the effects of feedback competition on feedback ...
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