Stabilization of Metastable Indomethacin α in Cellulose Nanocrystal Aerogel Scaffolds
Abstract
Indomethacin (IM) is a small molecule active pharmaceutical ingredient (API) that exhibits polymorphism with the γ-form being the most thermodynamically stable form of the drug. The α-form is metastable, but it exhibits higher solubility, making it a more attractive form for drug delivery. As with other metastable polymorphs, α-IM undergoes interconversion to the stable form when subjected to certain stimuli, such as solvent, heat, pH, or...
Paper Details
Title
Stabilization of Metastable Indomethacin α in Cellulose Nanocrystal Aerogel Scaffolds
Published Date
Mar 24, 2021
Journal
Volume
13
Issue
4
Pages
441 - 441
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