Pharmaceutics
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#1Natalia Lange (Wrocław Medical University)
#2Wojciech Szlasa (Wrocław Medical University)H-Index: 2
Last. Agnieszka Chwiłkowska (Wrocław Medical University)H-Index: 11
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Photodynamic therapy (PDT) is a method of cancer treatment that leads to the disintegration of cancer cells and has developed significantly in recent years. The clinically used photosensitizers are primarily porphyrin, which absorbs light in the red spectrum and their absorbance maxima are relatively short. This review presents group of compounds and their derivatives that are considered to be potential photosensitizers in PDT. Cyanine dyes are compounds that typically absorb light in the visibl...
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#1Tsuyoshi Yamamoto (Nagasaki University)H-Index: 15
#2Yahiro Mukai (Osaka University)
Last. Mariko Harada-ShibaH-Index: 39
view all 9 authors...
The development of clinically relevant anti-microRNA antisense oligonucleotides (anti-miRNA ASOs) remains a major challenge. One promising configuration of anti-miRNA ASOs called "tiny LNA (tiny Locked Nucleic Acid)" is an unusually small (~8-mer), highly chemically modified anti-miRNA ASO with high activity and specificity. Within this platform, we achieved a great enhancement of the in vivo activity of miRNA-122-targeting tiny LNA by developing a series of N-acetylgalactosamine (GalNAc)-conjug...
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#1Sin-Eun Kim (KNU: Kyungpook National University)
#2Seung-Bae Ji (KNU: Kyungpook National University)
Last. Kwang-Hyeon Liu (KNU: Kyungpook National University)H-Index: 31
view all 14 authors...
DN203368 ((E)-3-[1-(4-[4-isopropylpiperazine-1-yl]phenyl) 3-methyl-2-phenylbut-1-en-1-yl] phenol) is a 4-hydroxy tamoxifen analog that is a dual inverse agonist of estrogen-related receptor β/γ (ERRβ/γ). ERRγ is an orphan nuclear receptor that plays an important role in development and homeostasis and holds potential as a novel therapeutic target in metabolic diseases such as diabetes mellitus, obesity, and cancer. ERRβ is also one of the orphan nuclear receptors critical for many biological pro...
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#1Yi-Hsien Shih (TMU: Taipei Medical University)
#2Donald Liu (TMU: Taipei Medical University)H-Index: 3
Last. Shing-Chuan Shen (TMU: Taipei Medical University)H-Index: 13
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Biofilms of Cutibacterium (C.) acnes (formerly Propionibacterium acnes) are responsible for the persistence and antibiotic resistance of acne vulgaris. In addition to the standard treatments for acne vulgaris, a common adjunctive treatment is the topical administration of nicotinamide (NAM). However, the effects of NAM on biofilms of C. acnes have never been explored. This study comprehensively investigates the effects of NAM against biofilms of C. acnes using in vitro and in vivo approaches. Th...
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#1Angela Abruzzo (UNIBO: University of Bologna)H-Index: 11
#2Carola Eleonora Parolin (UNIBO: University of Bologna)H-Index: 18
Last. Barbara Luppi (UNIBO: University of Bologna)H-Index: 26
view all 9 authors...
One of the most widely used strategies to improve drug diffusion through the skin is the use of permeation enhancers. The aim of this work was to investigate the effect of two biosurfactants (BS), produced by Lactobacillus crispatus BC1 and Lactobacillus gasseri BC9, on the skin permeation profile of hydrocortisone (HC, model drug). HC aqueous solubility and in vitro diffusion studies through porcine skin were performed in the presence of BC1-BS and BC9-BS at concentrations below and above criti...
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#1Yuxuan Ge (SJTU: Shanghai Jiao Tong University)
#2Zhenhua Hu (SJTU: Shanghai Jiao Tong University)H-Index: 8
Last. Tuo Jin (SJTU: Shanghai Jiao Tong University)H-Index: 20
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GLP-1 receptor agonists are a class of diabetes medicines offering self-regulating glycemic efficacy and may best be administrated in long-acting forms. Among GLP-1 receptor agonists, exenatide is the one requiring the least dose so that controlled-release poly(d, l-lactic-co-glycolic acid) (PLGA) microspheres may best achieve this purpose. Based on this consideration, the present study extended the injection interval of exenatide microspheres from one week of the current dosage form to four wee...
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The pandemic of the coronavirus disease 2019 (COVID-19) represents an unprecedented challenge to identify effective drugs for prevention and treatment. While the world's attention is focused on news of COVID-19 vaccine updates, clinical management still requires improvement. Due to the similarity of cancer-induced inflammation, immune dysfunction, and coagulopathy to COVID-19, anticancer drugs, such as Interferon, Pembrolizumab or Bicalutamide, are already being tested in clinical trials for rep...
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#1Wei-Feng Zhu (MOE: Chinese Ministry of Education)
#2Lin Zhu (MOE: Chinese Ministry of Education)
Last. Liang-Shan Ming (MOE: Chinese Ministry of Education)
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It is necessary to prepare porous lactose in order to improve the dissolution behavior of insoluble active ingredient. In this study, polyvinylpyrrolidone K30 (PVP K30) was firstly utilized as a templating agent with different use levels in preparing porous lactose. Then, the physical properties were profoundly characterized. Finally, the porous lactose was also employed as a health functional food/drug carrier to explore the effect on the dissolution behavior of curcumin. The results confirmed ...
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#1Nikita Hanning (University of Antwerp)H-Index: 3
#2Michelle De bruyn (University of Antwerp)H-Index: 1
Last. Benedicte Y. De Winter (University of Antwerp)H-Index: 31
view all 13 authors...
Dysregulation of the protease-antiprotease balance in the gastrointestinal tract has been suggested as a mechanism underlying visceral hypersensitivity in conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). We aimed to study the potential therapeutic role of an intracolonically administered serine protease inhibitor for the treatment of abdominal pain in a post-inflammatory rat model for IBS. An enema containing 2,4,6-trinitrobenzene sulfonic acid (TNBS) was u...
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#1Yoo-Seong Jeong (SNU: Seoul National University)H-Index: 5
#2Minsoo Kim (SNU: Seoul National University)H-Index: 52
Last. Kyeong-Ryoon Lee (Korea Research Institute of Bioscience and Biotechnology)H-Index: 2
view all 7 authors...
Fexuprazan is a new drug candidate in the potassium-competitive acid blocker (P-CAB) family. As proton pump inhibitors (PPIs), P-CABs inhibit gastric acid secretion and can be used to treat gastric acid-related disorders such as gastroesophageal reflux disease (GERD). Physiologically based pharmacokinetic (PBPK) models predict drug interactions as pharmacokinetic profiles in biological matrices can be mechanistically simulated. Here, we propose an optimized and validated PBPK model for fexupraza...
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