Polyploid giant cancer cell characterization: New frontiers in predicting response to chemotherapy in breast cancer
Abstract
Although polyploid cells were first described nearly two centuries ago, their ability to proliferate has only recently been demonstrated. It also becomes increasingly evident that a subset of tumor cells, polyploid giant cancer cells (PGCCs), play a critical role in the pathophysiology of breast cancer (BC), among other cancer types. In BC, PGCCs can arise in response to therapy-induced stress. Their progeny possess cancer stem cell (CSC)...
Paper Details
Title
Polyploid giant cancer cell characterization: New frontiers in predicting response to chemotherapy in breast cancer
Published Date
Jun 1, 2022
Journal
Volume
81
Pages
220 - 231
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