Advanced bandages for diabetic wound healing.

Published on Mar 17, 2021in Science Translational Medicine16.304
Simon Matoori9
Estimated H-index: 9
(Wyss Institute for Biologically Inspired Engineering),
Simon Matoori (Wyss Institute for Biologically Inspired Engineering)+ 0 AuthorsDavid J. Mooney164
Estimated H-index: 164
(Wyss Institute for Biologically Inspired Engineering)
Current treatment options for foot ulcers, a serious and prevalent complication of diabetes, remain nonspecific. In this Perspective, we present recent advances in understanding the pathophysiology of diabetic wound healing and the emergence of previously unidentified targets. We discuss wound dressings tailored to the diabetic wound environment currently under development.
#1Georgios Theocharidis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
#2Dimitrios Baltzis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 76
view all 16 authors...
Non-healing diabetic foot ulceration (DFU) is characterized by low grade chronic inflammation, both locally and systemically. We prospectively followed a group of DFU patients who either healed or developed non-healing chronic DFU. Serum and forearm skin analysis, both at protein expression and transcriptomic level, indicated that increased expression of factors such as IFNγ, VEGF and sVCAM-1 were associated with DFU healing. Furthermore, foot skin single-cell RNA-seq analysis showed multiple fi...
5 CitationsSource
#1Ana Tellechea (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 14
#2Sha Bai (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 3
Last. Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 76
view all 20 authors...
ABSTRACT Impaired wound healing in the diabetic foot is a major problem often leading to amputation. Mast cells have been shown to regulate wound healing in diabetes. We developed an indole-carboxamide type mast cell stabilizer, MCS-01, which proved to be an effective mast cell degranulation inhibitor in vitro and can be delivered topically for prolonged periods through controlled release by specifically designed alginate bandages. In diabetic mice, both pre- and post-wounding, topical MCS-01 ap...
13 CitationsSource
#1Nicolaas C. SchaperH-Index: 70
#2Jaap J. van Netten (QUT: Queensland University of Technology)H-Index: 20
Last. Benjamin A. Lipsky (Geneva College)H-Index: 93
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Diabetic foot disease results in a major global burden for patients and the health care system. The International Working Group on the Diabetic Foot (IWGDF) has been producing evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. In 2019, all IWGDF Guidelines have been updated based on systematic reviews of the literature and formulation of recommendations by multidisciplinary experts from all over the world. In this document, the IWGDF Practical Guideli...
53 CitationsSource
#1Georgios Theocharidis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 6
#2Aristidis Veves (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 76
Abstract Lower extremity ulcerations represent a major complication in diabetes mellitus and involve multiple physiological factors that lead to impairment of wound healing. Neuropeptides are neuromodulators implicated in various processes including diabetic wound healing. Diabetes causes autonomic and small sensory nerve fibers neuropathy as well as inflammatory dysregulation, which manifest with decreased neuropeptide expression and a disproportion in pro- and anti- inflammatory cytokine respo...
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#1Sine Hangaard (Steno Diabetes Center)H-Index: 1
#2Anne Rasmussen (Steno Diabetes Center)H-Index: 8
Last. Per Holstein (Steno Diabetes Center)H-Index: 1
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Abstract Aim Diabetic foot ulcer (DFU) is a major complication of both Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D); however research into risk factors for DFU does not separate between these two types. The purpose of the present investigation was to identify risk factors for development of first time DFU (FTDFU) over a period of 15 years in patients with T1D and T2D separately. Methods This retrospective cohort study included 25,220 feet from 5588 patients with T1D and 7113 patients with T2D...
6 CitationsSource
#1Sang Yong Kim (UCR: University of California, Riverside)H-Index: 3
#2Meera G. Nair (UCR: University of California, Riverside)H-Index: 24
Author(s): Kim, Sang Yong; Nair, Meera G | Abstract: Macrophages are critically involved in wound healing, from dampening inflammation to clearing cell debris and coordinating tissue repair. Within the wound, the complexity of macrophage function is increasingly recognized, with adverse outcomes when macrophages are inappropriately activated, such as in fibrosis or chronic non-healing wounds. Recent advances in in vivo and translational wound models, macrophage-specific deletions and new technol...
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#1Trung T. Nguyen (ND: University of Notre Dame)H-Index: 5
#2Derong Ding (ND: University of Notre Dame)H-Index: 9
Last. Mayland Chang (ND: University of Notre Dame)H-Index: 33
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Diabetic foot ulcers (DFUs) are a significant health problem. A single existing FDA-approved drug for this ailment, becaplermin, is not standard-of-care. We previously demonstrated that upregulation of active matrix metalloproteinase (MMP)-9 is the reason that the diabetic wound in mice is recalcitrant to healing and that MMP-8 participates in wound repair. In the present study, we validate the target MMP-9 by identifying and quantifying active MMP-8 and MMP-9 in human diabetic wounds using an a...
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#1Lara Lopes (Yale University)H-Index: 3
#2Ocean Setia (Yale University)H-Index: 3
Last. Alan Dardik (Yale University)H-Index: 53
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Background Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders that result in poor wound healing and poor treatment options. Recently, stem cell therapy has emerged as a new interventional strategy to treat DFU and appears to be safe and effective in both preclin...
38 CitationsSource
#1Yunxiao Zhu (NU: Northwestern University)H-Index: 9
#2Zdravka Cankova (NU: Northwestern University)H-Index: 3
Last. Guillermo A. Ameer (NU: Northwestern University)H-Index: 41
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The successful treatment of chronic dermal wounds, such as diabetic foot ulcers (DFU), depends on the development of safe, effective, and affordable regenerative tools that the surgeon can rely on to promote wound closure. Although promising, strategies that involve cell-based therapies and the local release of exogenous growth factors are costly, require very long development times, and result in modest improvements in patient outcome. We describe the development of an antioxidant shape-conform...
36 CitationsSource
#1Jun Ishihara (U of C: University of Chicago)H-Index: 11
#2Ako Ishihara (U of C: University of Chicago)H-Index: 9
Last. Jeffrey A. Hubbell (U of C: University of Chicago)H-Index: 136
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Laminin, as a key component of the basement membrane extracellular matrix (ECM), regulates tissue morphogenesis. Here, we show that multiple laminin isoforms promiscuously bind to growth factors (GFs) with high affinity, through their heparin-binding domains (HBDs) located in the α chain laminin-type G (LG) domains. These domains also bind to syndecan cell-surface receptors, promoting attachment of fibroblasts and endothelial cells. We explore the application of these multifunctional laminin HBD...
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Cited By0
#1Prarthana Patil (Vandy: Vanderbilt University)H-Index: 2
#2Katherine A Russo (Vandy: Vanderbilt University)
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Impaired skin healing and progression into chronic wounds is a prevalent and growing medical problem. Porous, resorbable biomaterials can be used as temporary substrates placed into skin defects to support cell infiltration, neo-tissue formation, and remodeling of nonhealing wounds. Naturally-derived biomaterials have promising healing benefits, but their low mechanical properties and exuberant costs limit their performance and use. Synthetic materials can be affordably manufactured and tuned ac...