Original paper
Establishment of functional epithelial organoids from human lacrimal glands
Abstract
Background Tear deficiency due to lacrimal gland (LG) dysfunction is one of the major causes of dry eye disease (DED). Therefore, LG stem cell-based therapies have been extensively reported to regenerate injured lacrimal tissue; however, the number of stem cells in the LG tissue is low, and 2D long-term cultivation reduces the differentiation capacity of stem cells. Nevertheless, 3D LG organoids could be an alternative for a DED therapy because...
Paper Details
Title
Establishment of functional epithelial organoids from human lacrimal glands
Published Date
Apr 21, 2021
Journal
Volume
12
Issue
1
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Notes
History