Stem Cell Research & Therapy
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#1Pietro Gentile (University of Rome Tor Vergata)H-Index: 36
#2Aris SterodimasH-Index: 4
Last. Simone Garcovich (UCSC: Catholic University of the Sacred Heart)H-Index: 21
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Fat tissue (FT) has been used for many years in regenerative surgery as a bioactive material through the lipofilling/fat graft (F-GRF)-nano-fat technique, as a bioactive scaffold when it was enriched with adipose-derived mesenchymal stem cells (AD-MSCs) contained in the stromal vascular fraction (SVF), and as a direct source of AD-MSCs used in wound healing (WH) and scar treatment (ST). This systematic review aims to describe the advances in FT engineering applied to regenerative surgery (from b...
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#1Rachele Ciccocioppo (University of Verona)H-Index: 30
#2Davide Gibellini (University of Verona)H-Index: 40
Last. Vincenzo Bronte (University of Verona)H-Index: 82
view all 22 authors...
Coronavirus disease 2019 (COVID-19) may result in a life-threatening condition due to a hyperactive immune reaction to severe acute respiratory syndrome-coronavirus-2 infection, for which no effective treatment is available. Based on the potent immunomodulatory properties of mesenchymal stromal cells (MSCs), a growing number of trials are ongoing. This prompted us to carry out a thorough immunological study in a patient treated with umbilical cord-derived MSCs and admitted to the Intensive Care ...
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#1Bao-Shi Fan (PKU: Peking University)H-Index: 1
#2Yang Liu (PKU: Peking University)H-Index: 1
Last. Jia-Kuo Yu (PKU: Peking University)H-Index: 21
view all 6 authors...
BACKGROUND The stem cells of the stem cell banks have prominent problems for insufficient sources, easy contamination, unstable biological characteristics after serial subcultivations, and high cost. METHODS After collecting the construction processes of the existing stem cell banks and suggestions from authoritative experts in the past 10 years, 230 reference principles were obtained, and finally, the principles of "5C" for the establishment of modern standardized stem cell banks were summarize...
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BACKGROUND The intestine is particularly sensitive to moderate-high radiation dose and the development of gastrointestinal syndrome (GIS) leads to the rapid loss of intestinal mucosal integrity, resulting in bacterial infiltration, sepsis that comprise patient survival. There is an urgent need for effective and rapid therapeutic countermeasures. The stromal vascular fraction (SVF) derived from adipose tissue is an easily accessible source of cells with angiogenic, anti-inflammatory and regenerat...
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#1Chengxin Luo (Third Military Medical University)H-Index: 1
#2Li Wang (CQMU: Chongqing Medical University)H-Index: 88
Last. Jieping Chen (Third Military Medical University)H-Index: 5
view all 16 authors...
BACKGROUND Mobilization failure may occur when the conventional hematopoietic stem cells (HSCs) mobilization agent granulocyte colony-stimulating factor (G-CSF) is used alone, new regimens were developed to improve mobilization efficacy. Multiple studies have been performed to investigate the efficacy of these regimens via animal models, but the results are inconsistent. We aim to compare the efficacy of different HSC mobilization regimens and identify new promising regimens with a network meta-...
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#1Shao-Peng Yang (Hebei Medical University)
#2Xiaonan Liang (Hebei Medical University)
Last. Xiaolan Zhang (Hebei Medical University)H-Index: 10
view all 9 authors...
BACKGROUND Exosomes as the main therapeutic vectors of mesenchymal stem cells (MSC) for inflammatory bowel disease (IBD) treatment and its mechanism remain unexplored. Tumor necrosis factor-α stimulated gene 6 (TSG-6) is a glycoprotein secreted by MSC with the capacities of tissue repair and immune regulation. This study aimed to explore whether TSG-6 is a potential molecular target of exosomes derived from MSCs (MSCs-Exo) exerting its therapeutic effect against colon inflammation and repairing ...
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#1Xihang Chen (Southern Medical University)H-Index: 3
#2Jingwei Feng (Southern Medical University)H-Index: 6
Last. Yi Yuan (Southern Medical University)H-Index: 8
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BACKGROUND Fat grafting has been regarded as a promising approach for regenerative therapy. Given the rapidly aging population, better understanding of the effect of age on fat graft outcomes and the underlying mechanisms is urgently needed. METHODS C57/BL6 mice [old (O, 18-20-month-old) and young (Y, 4-month-old)] were randomized to four fat graft groups [old-to-old (O-O), young-to-young (Y-Y), old-to-young (O-Y), and young-to-old (Y-O)]. Detailed cellular events before and after grafting were ...
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#1Sung-Tai Wei (China Medical University (Taiwan))H-Index: 4
#2Yen-Chih Huang (China Medical University (Taiwan))H-Index: 8
Last. Chia Hung Hsieh (China Medical University (Taiwan))H-Index: 18
view all 8 authors...
BACKGROUND The major barriers to mesenchymal stem cell (MSC) therapy in rheumatoid arthritis (RA) are a low extent of tissue regeneration and insufficient immunomodulation after cell transplantation. In addition, the role of C-X-C chemokine receptor type 7 (CXCR7) and its mechanism of action in MSC-mediated osteogenic or chondrogenic differentiation and immunomodulation are unclear. METHODS Gain of CXCR7 function on human MSCs was carried out by lentiviral vector-mediated CXCR7 overexpression or...
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#1Norihisa Ichinohe (Sapporo Medical University)H-Index: 11
#2Masayuki Ishii (Sapporo Medical University)H-Index: 11
Last. Toshihiro Mitaka (Sapporo Medical University)H-Index: 39
view all 8 authors...
BACKGROUND Small hepatocyte-like progenitor cells (SHPCs) appear to form transient clusters in rat livers treated with retrorsine (Ret) and 70% partial hepatectomy (PH). We previously reported that the expansion of SHPCs was amplified in Ret/PH-treated rat livers transplanted with Thy1+ cells derived from D-galactosamine-treated injured livers. Extracellular vesicles (EVs) produced by hepatic Thy1+ donor cells activated SHPCs via interleukin (IL)-17 receptor B signaling. As bone marrow-derived m...
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#1Yuqian Jiang (PSU: Pennsylvania State University)H-Index: 3
#2Xiaoping Bao (Purdue University)H-Index: 14
Last. Xiaojun Lance Lian (PSU: Pennsylvania State University)H-Index: 3
view all 3 authors...
Cardiovascular diseases (CVD) remain the leading cause of death in the USA. Cardiomyocytes (CMs) derived from human pluripotent stem cells (hPSCs) provide a valuable cell source for regenerative therapy, disease modeling, and drug screening. Here, we established a hPSC line integrated with a mCherry fluorescent protein driven by the alpha myosin heavy chain (aMHC) promoter, which could be used to purify CMs based on the aMHC promoter activity in these cells. Combined with a fluorescent voltage i...
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Top fields of study
Mesenchymal stem cell
Immunology
Stem cell
Medicine
Biology
Cell biology