Stem Cell Research & Therapy
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Background Tear deficiency due to lacrimal gland (LG) dysfunction is one of the major causes of dry eye disease (DED). Therefore, LG stem cell-based therapies have been extensively reported to regenerate injured lacrimal tissue; however, the number of stem cells in the LG tissue is low, and 2D long-term cultivation reduces the differentiation capacity of stem cells. Nevertheless, 3D LG organoids could be an alternative for a DED therapy because it is capable of prolonged growth while maintaining...
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#2Xing H (ZJU: Zhejiang University)
Last. Ning Zhang (ZJU: Zhejiang University)H-Index: 2
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#1Liqiang Zhang (Xi'an Jiaotong University)
#2Jiangdong Zhao (Fourth Military Medical University)H-Index: 4
Last. Wenjia Liu (Xi'an Jiaotong University)H-Index: 1
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#1Xuejun Ni (Fujian Medical University)H-Index: 1
#2Xiuying Shan (Fujian Medical University)H-Index: 1
Last. Biao Wang (Fujian Medical University)H-Index: 4
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Background Wound healing is impaired in patients with diabetes due to the multifactorial etiology of the disease, which limits the therapeutic efficacy of various approaches. This study hypothesizes that the combination of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) might achieve optimally efficient diabetic wound healing. Methods ADSCs were isolated from the adipose tissues of Sprague-Dawley (SD) rats. PRP was prepared by using a two-step centrifugation technique. A diabet...
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#1Tahereh Rostami (Tehran University of Medical Sciences)H-Index: 3
#2Amir Kasaeian (Tehran University of Medical Sciences)H-Index: 66
Last. Ardeshir Ghavamzadeh (Tehran University of Medical Sciences)H-Index: 27
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BACKGROUND Hepatic fibrosis is a common complication in transfusion-dependent thalassemia patients. Data on the co-transplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) in beta-thalassemia major patients are scarce. Therefore, we aimed to evaluate the effect of co-transplantation of bone marrow-derived MSC with HSCs on the liver fibrosis alleviation and transplant outcomes in class III beta-thalassemia major. METHODS Between April 1998 and January 2017, a total of...
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Radiation-induced lung injury (RILI) is one of the most common complications associated with radiotherapy, characterized by early-stage radiation pneumonia and subsequent radiation pulmonary fibrosis. However, effective therapeutic strategies for RILI are currently lacking. Recently, an increasing number of studies reported that mesenchymal stem cells (MSCs) can enhance the regeneration of damaged tissue, modulate the inflammatory response, reduce the levels of fibrotic cytokines and reactive ox...
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#1Margaret Lamb (Nationwide Children's Hospital)H-Index: 1
#2Hemalatha G. Rangarajan (Nationwide Children's Hospital)H-Index: 7
Last. Dean A. Lee (Nationwide Children's Hospital)H-Index: 40
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The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti-tumor immune response in a wide range of malignancies, most notably with early evidence of efficacy in hematologic malignancies. NK cells are dysfunctional in patients with hematologic malignancies, and their number and function are further impaired by chemotherapy, radiation, and immunosuppressants used in initial thera...
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#1Zhang Yuting (Soochow University (Suzhou))
#2Kai-jie He (Soochow University (Suzhou))
Last. Chun-Feng Liu (Soochow University (Suzhou))H-Index: 35
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Stem cells are characterized by their self-renewal and multipotency and have great potential in the therapy of various disorders. However, the blood-brain barrier (BBB) limits the application of stem cells in the therapy of neurological disorders, especially in a noninvasive way. It has been shown that small molecular substances, macromolecular proteins, and even stem cells can bypass the BBB and reach the brain parenchyma following intranasal administration. Here, we review the possible brain-e...
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#1Zhi Chen (HUST: Huazhong University of Science and Technology)
#2Xiang Ren (HUST: Huazhong University of Science and Technology)
Last. Jiwen Shang (HUST: Huazhong University of Science and Technology)
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BACKGROUND Several studies have confirmed that mobilizing bone marrow-derived stem cells (BMSCs) ameliorates renal function loss following cisplatin-induced acute kidney injury (AKI). The aim of this study was to explore whether the combination of granulocyte-colony stimulating factor (G-CSF) and plerixafor (AMD3100) exerts beneficial effects on renal function recovery in a model of cisplatin-induced nephrotoxicity. METHODS C57BL/6J mice received intraperitoneal injections of G-CSF (200 μg/kg/da...
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#1Rachael Mooney (Beckman Research Institute)H-Index: 12
#2Wafa Abidi (Beckman Research Institute)H-Index: 2
Last. Karen S. Aboody (Beckman Research Institute)H-Index: 13
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BACKGROUND Immortalized, clonal HB1.F3.CD 21 human neural stem/progenitor cells (NSCs), loaded with therapeutic cargo prior to intraperitoneal (IP) injection, have been shown to improve the delivery and efficacy of therapeutic agents in pre-clinical models of stage III ovarian cancer. In previous studies, the distribution and efficacy of the NSC-delivered cargo has been examined; however, the fate of the NSCs has not yet been explored. METHODS To monitor NSC tropism, we used an unconventional me...
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Top fields of study
Mesenchymal stem cell
Immunology
Stem cell
Medicine
Biology
Cell biology