Stem Cell Research & Therapy
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#1Ryota Chijimatsu (UTokyo: University of Tokyo)H-Index: 9
#2Satoshi Miwa (UTokyo: University of Tokyo)H-Index: 1
Last. Shin Sameshima (UTokyo: University of Tokyo)H-Index: 3
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#1Boya Li (PKU: Peking University)
#2Yixiao Xing (PKU: Peking University)
Last. Hong Hua (PKU: Peking University)H-Index: 13
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BACKGROUND Sjogren's syndrome (SS) is a chronic, systemic autoimmune disorder characterized by sicca syndrome and/or systemic manifestations. The disease severely affects the health and life of patients, and the treatment of SS has always been a clinical challenge and essentially palliative. Mesenchymal stem cells (MSCs) have been reported to exert immunomodulatory effects and as a potential novel therapeutic strategy for SS. Labial gland-derived MSCs (LGMSCs) are a population of resident stem c...
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#1Zuxiang Chen (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
#2Yanzhi Ge (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
Last. Peijian Tong (ZJNU: Zhejiang Chinese Medical University)H-Index: 18
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BACKGROUND Osteoarthritis (OA) is the most common joint degenerative disorder, with little effective therapy to date. Nanofat is a cocktail of cells obtained from fat tissue, which possesses regenerative capacity and has a potential in treating OA. This study aimed to determine the anti-OA efficacy of Nanofat from basic and clinical aspects and explore its action mode. METHODS Flow cytometry was performed to characterize Nanofat. A monoiodoacetate-induced OA rat model was employed for in vivo st...
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#1Akiko Tanuma-Takahashi (Jikei University School of Medicine)H-Index: 1
#2Momoko Inoue (Jikei University School of Medicine)H-Index: 2
Last. Aikou Okamoto (Jikei University School of Medicine)H-Index: 28
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BACKGROUND An extra copy of chromosome 21 in humans can alter cellular phenotypes as well as immune and metabolic systems. Down syndrome is associated with many health-related problems and age-related disorders including dermatological abnormalities. However, few studies have focused on the impact of trisomy 21 (T21) on epidermal stem cells and progenitor cell dysfunction. Here, we investigated the differences in keratinocytic characteristics between Down syndrome and euploid cells by differenti...
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#1Hiroshi Takahashi (Hiroshima University)H-Index: 3
#2Taku Nakashima (Hiroshima University)H-Index: 15
Last. Kazunori Fujitaka (Hiroshima University)H-Index: 18
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BACKGROUND Aldehyde dehydrogenase (ALDH) is highly expressed in stem/progenitor cells in various tissues, and cell populations with high ALDH activity (ALDHbr) are associated with tissue repair. However, little is known about lung-resident ALDHbr. This study was performed to clarify the characteristics of lung-resident ALDHbr cells and to evaluate their possible use as a tool for cell therapy using a mouse model of bleomycin-induced pulmonary fibrosis. METHODS The characteristics of lung-residen...
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#1Nouri Arezoo (Shiraz University)
#2Hajian Mohammad (Shiraz University)
Last. Monsefi Malihezaman (Shiraz University)H-Index: 1
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BACKGROUND Uterine tissue engineering can provide the opportunity for curing female infertility. Natural scaffold is a good choice to recapitulate the architecture and functionality of the native tissue. In this study, we purposed the potential of uterine decellularized scaffolds as an adequate natural niche for MenSCs differentiation toward uterus-specific cell lineages. METHODS Mouse's uterus was decellularized by immersion of hypo and hypertonic salts or freeze-thaw cycle followed by immersio...
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#1Yue Kong (Fudan University)H-Index: 1
#2Yang Shao (Fudan University)H-Index: 7
Last. Gong Yang (Fudan University)H-Index: 79
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Endometrial stem/progenitor cells have been proved to exist in periodically regenerated female endometrium and can be divided into three categories: endometrial epithelial stem/progenitor cells, CD140b+CD146+ or SUSD2+ endometrial mesenchymal stem cells (eMSCs), and side population cells (SPs). Endometrial stem/progenitor cells in the menstruation blood are defined as menstrual stem cells (MenSCs). Due to their abundant sources, excellent proliferation, and autotransplantation capabilities, MenS...
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#1Yunyu Zhao (Xi'an Jiaotong University)
#2Zhipeng Yan (Shaanxi University of Chinese Medicine)
Last. Ji F (Xi'an Jiaotong University)
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Pulmonary fibrosis (PF) is a chronic, progressive, fibrotic interstitial disease of the lung with poor prognosis and without effective treatment currently. Data from previous coronavirus infections, such as the Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome, as well as current clinical evidence from the Coronavirus disease 2019 (COVID-19), support that SARS-CoV-2 infection may lead to PF, seriously impacting patient prognosis and quality of life. Therefore, effecti...
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#1Keya Li (Peking Union Medical College)
#2Guiying Shi (Peking Union Medical College)H-Index: 5
Last. Chuan Qin (Peking Union Medical College)H-Index: 1
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BACKGROUND AND OBJECTIVES Adipose tissue-derived stem cells (ADSCs) autologous transplantation has been a promising strategy for aging-related disorders. However, the relationship between ADSCs senescence and organismal aging has not been clearly established. Therefore, we aimed at evaluating senescence properties of ADSCs from different age donors and to verify the influence of organismal aging on the proliferation and function of ADSCs in vitro, providing the theoretical basis for the clinical...
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#1Naoki Ishiuchi (Hiroshima University)H-Index: 1
#2Ayumu Nakashima (Hiroshima University)H-Index: 23
Last. Takao Masaki (Hiroshima University)H-Index: 19
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Background null Mesenchymal stem cells (MSCs) repair injured tissue in a paracrine manner. To enhance their therapeutic properties, preconditioning with various factors has been researched. We have previously showed that MSCs cultured in serum-free medium (SF-MSCs) promote their immunosuppressive ability, thereby enhancing their anti-fibrotic effect. Here, we examined whether serum-free medium and hypoxic preconditioning synergistically enhance the therapeutic effects of MSCs on renal fibrosis i...
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Top fields of study
Mesenchymal stem cell
Immunology
Stem cell
Medicine
Biology
Cell biology