A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
Abstract
Malaria elimination requires tools that interrupt parasite transmission. Here, we characterize B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230 kDa gamete surface protein Pfs230, a key protein in sexual stage development of P. falciparum parasites. Among nine Pfs230 human monoclonal antibodies (mAbs) that we generated, one potently blocks transmission to mosquitoes in a...
Paper Details
Title
A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
Published Date
Mar 19, 2021
Journal
Volume
12
Issue
1
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