Review paper

Fibroblast growth factor receptor (FGFR) gene: pathogenesis and treatment implications in urothelial carcinoma of the bladder

Volume: 74, Issue: 8, Pages: 491 - 495
Published: Mar 17, 2021
Abstract
Dysregulation of fibroblast growth factor receptors ( FGFRs ) has been implicated in several human malignancies, including urothelial carcinoma. In urothelial carcinoma, the oncogenic role of mutated FGFR is mediated by the RAS-mitogen-activated protein kinase pathway, resembling the effects observed with activated HRAS . Activating somatic mutations of FGFR3 are clustered in three hotspots in exons 7, 10 and 15, and are almost always missense...
Paper Details
Title
Fibroblast growth factor receptor (FGFR) gene: pathogenesis and treatment implications in urothelial carcinoma of the bladder
Published Date
Mar 17, 2021
Volume
74
Issue
8
Pages
491 - 495
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